Kinetics of SARS-CoV-2 anti-S IgG after BNT162b2 vaccination.
BNT162b2
IgG kinetics
SARS-CoV-2
Serology
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
07 09 2021
07 09 2021
Historique:
received:
08
03
2021
revised:
04
08
2021
accepted:
07
08
2021
pubmed:
17
8
2021
medline:
3
9
2021
entrez:
16
8
2021
Statut:
ppublish
Résumé
Deployment of the BNT162b2 mRNA Covid-19 Vaccine in Israel began in December 2020. This is a retrospective analysis of serological data, showing SARS-CoV-2 anti-S IgG kinetics in 116 Israeli health care workers receiving BNT162b2. Sero-conversion occurred in 14 days in all study participants, with IgG levels peaking approximately 30 days after initiation of the vaccination series. A statistically significant difference was observed in IgG levels between subjects younger than 50 years and older participants, although in all cases, IgG levels were well above the level considered reactive by the test's manufacturer. The importance of this difference needs to be studied further, but a potential difference in vaccine efficacy and vaccine effect length could possibly be present between these two groups.
Identifiants
pubmed: 34393018
pii: S0264-410X(21)01045-8
doi: 10.1016/j.vaccine.2021.08.025
pmc: PMC8354802
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
Immunoglobulin G
0
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5337-5340Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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