Computational Analysis of Gly482Ser Single-Nucleotide Polymorphism in PPARGC1A Gene Associated with CAD, NAFLD, T2DM, Obesity, Hypertension, and Metabolic Diseases.
Journal
PPAR research
ISSN: 1687-4757
Titre abrégé: PPAR Res
Pays: United States
ID NLM: 101269101
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
02
2021
revised:
28
06
2021
accepted:
07
07
2021
entrez:
16
8
2021
pubmed:
17
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PPARGC1A) regulates the expression of energy metabolism's genes and mitochondrial biogenesis. The essential roles of PPARGC1A encouraged the researchers to assess the relation between metabolism-related diseases and its variants. To study Gly482Ser (+1564G/A) single-nucleotide polymorphism (SNP) after PPARGC1A modeling, we substitute Gly482 for Ser482. Stability prediction tools showed that this substitution decreases the stability of PPARGC1A or has a destabilizing effect on this protein. We then utilized molecular dynamics simulation of both the Gly482Ser variant and wild type of the PPARGC1A protein to analyze the structural changes and to reveal the conformational flexibility of the PPARGC1A protein. We observed loss flexibility in the RMSD plot of the Gly482Ser variant, which was further supported by a decrease in the SASA value in the Gly482Ser variant structure of PPARGC1A and an increase of H-bond with the increase of
Identifiants
pubmed: 34394332
doi: 10.1155/2021/5544233
pmc: PMC8360745
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5544233Informations de copyright
Copyright © 2021 Somayye Taghvaei et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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