Convulsive Status Epilepticus in a Cohort of Patients from a Peruvian Academic Hospital.
Epilepsy
Peru
Status epilepticus
Journal
Journal of epilepsy research
ISSN: 2233-6249
Titre abrégé: J Epilepsy Res
Pays: Korea (South)
ID NLM: 101577886
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
20
02
2021
revised:
11
05
2021
accepted:
16
05
2021
entrez:
16
8
2021
pubmed:
17
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
Status epilepticus is a neurologic emergency whose epidemiology, etiology and management are scarcely known in developing countries. Our objective was to describe the demographic and clinical features as well as the management of generalized convulsive status epilepticus (GCSE) in adult patients admitted to the emergency department of an academic hospital in Peru, between March 2019 and March 2020. Observational study of a prospective cohort in which patients were assessed by the emergency and neurology department on the first day of hospitalization, at discharge and at 30 days post-discharge in a follow-up visit. Relevant demographics and clinical data were collected. After being encoded and sorted, univariate statistical analysis was carried out. Of the sample of 59 patients, 62.7% were males, 57.6% were unemployed, 89.8% did not finish high school, and 55.9% had intermittent GCSE with no seizure at arrival. The total calculated median times were: 60 minutes from GCSE onset to hospital arrival, 110 minutes from GCSE onset to 1st line therapy, and 7 minutes from hospital arrival to 1st line therapy. The most frequently used antiepileptic drugs were one dose of benzodiazepine (41.7%), phenytoin (76.9%), and additional doses of benzodiazepines (60%) for 1st, 2nd, and 3rd line therapies, respectively. The most frequent etiologies were antiepileptic drug suspension (27.1%), undetermined (25.4%) and acute stroke (11.8%). 62.71% had 0-2 modified Rankin score at discharge. In this cohort of patients, GCSE was mainly intermittent. Management times differed from the guidelines' recommendations.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Status epilepticus is a neurologic emergency whose epidemiology, etiology and management are scarcely known in developing countries. Our objective was to describe the demographic and clinical features as well as the management of generalized convulsive status epilepticus (GCSE) in adult patients admitted to the emergency department of an academic hospital in Peru, between March 2019 and March 2020.
METHODS
METHODS
Observational study of a prospective cohort in which patients were assessed by the emergency and neurology department on the first day of hospitalization, at discharge and at 30 days post-discharge in a follow-up visit. Relevant demographics and clinical data were collected. After being encoded and sorted, univariate statistical analysis was carried out.
RESULTS
RESULTS
Of the sample of 59 patients, 62.7% were males, 57.6% were unemployed, 89.8% did not finish high school, and 55.9% had intermittent GCSE with no seizure at arrival. The total calculated median times were: 60 minutes from GCSE onset to hospital arrival, 110 minutes from GCSE onset to 1st line therapy, and 7 minutes from hospital arrival to 1st line therapy. The most frequently used antiepileptic drugs were one dose of benzodiazepine (41.7%), phenytoin (76.9%), and additional doses of benzodiazepines (60%) for 1st, 2nd, and 3rd line therapies, respectively. The most frequent etiologies were antiepileptic drug suspension (27.1%), undetermined (25.4%) and acute stroke (11.8%). 62.71% had 0-2 modified Rankin score at discharge.
CONCLUSIONS
CONCLUSIONS
In this cohort of patients, GCSE was mainly intermittent. Management times differed from the guidelines' recommendations.
Identifiants
pubmed: 34395227
doi: 10.14581/jer.21011
pii: jer-21011
pmc: PMC8357561
doi:
Types de publication
Journal Article
Langues
eng
Pagination
83-92Informations de copyright
Copyright © 2021 Korean Epilepsy Society.
Déclaration de conflit d'intérêts
Conflict of Interest The authors declare that they have no conflicts of interest.
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