Eccrine Sweat Gland and Its Regeneration: Current Status and Future Directions.

eccrine sweat gland methods regeneration scaffolds signaling pathways stem cells

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2021
Historique:
received: 14 02 2021
accepted: 09 07 2021
entrez: 16 8 2021
pubmed: 17 8 2021
medline: 17 8 2021
Statut: epublish

Résumé

Eccrine sweat glands (ESGs) play an important role in temperature regulation by secreting sweat. Insufficiency or dysfunction of ESGs in a hot environment or during exercise can lead to hyperthermia, heat exhaustion, heatstroke, and even death, but the ability of ESGs to repair and regenerate themselves is very weak and limited. Repairing the damaged ESGs and regenerating the lost or dysfunctional ESGs poses a challenge for dermatologists and bum surgeons. To promote and accelerate research on the repair and regeneration of ESGs, we summarized the development, structure and function of ESGs, and current strategies to repair and regenerate ESGs based on stem cells, scaffolds, and possible signaling pathways involved.

Identifiants

pubmed: 34395417
doi: 10.3389/fcell.2021.667765
pmc: PMC8355620
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

667765

Informations de copyright

Copyright © 2021 Lin, Chen, Zhang, Xie, Du, Zhang and Li.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Yao Lin (Y)

Department of Plastic Surgery and Burn Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.

Liyun Chen (L)

Department of Plastic Surgery and Burn Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.

Mingjun Zhang (M)

Department of Plastic Surgery and Burn Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.

Sitian Xie (S)

Department of Plastic Surgery and Burn Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.

Lijie Du (L)

Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

Xiang Zhang (X)

Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

Haihong Li (H)

Department of Plastic Surgery and Burn Center, Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

Classifications MeSH