Post-translational Modifications of the Protein Termini.
C-terminome
Met-AP
N-terminome
acetylation
arginylation
lipidation
ubiquitination
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
06
2021
accepted:
30
06
2021
entrez:
16
8
2021
pubmed:
17
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
Post-translational modifications (PTM) involve enzyme-mediated covalent addition of functional groups to proteins during or after synthesis. These modifications greatly increase biological complexity and are responsible for orders of magnitude change between the variety of proteins encoded in the genome and the variety of their biological functions. Many of these modifications occur at the protein termini, which contain reactive amino- and carboxy-groups of the polypeptide chain and often are pre-primed through the actions of cellular machinery to expose highly reactive residues. Such modifications have been known for decades, but only a few of them have been functionally characterized. The vast majority of eukaryotic proteins are N- and C-terminally modified by acetylation, arginylation, tyrosination, lipidation, and many others. Post-translational modifications of the protein termini have been linked to different normal and disease-related processes and constitute a rapidly emerging area of biological regulation. Here we highlight recent progress in our understanding of post-translational modifications of the protein termini and outline the role that these modifications play
Identifiants
pubmed: 34395449
doi: 10.3389/fcell.2021.719590
pmc: PMC8358657
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
719590Subventions
Organisme : NINDS NIH HHS
ID : R01 NS102435
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122505
Pays : United States
Informations de copyright
Copyright © 2021 Chen and Kashina.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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