Extended Release of Metronidazole Drug Using Chitosan/Graphene Oxide Bionanocomposite Beads as the Drug Carrier.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
10 Aug 2021
10 Aug 2021
Historique:
received:
08
05
2021
accepted:
20
07
2021
entrez:
16
8
2021
pubmed:
17
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
This study depicts the facile approach for the synthesis of chitosan/graphene oxide bionanocomposite (Chi/GO) beads via the gelation process. This is the first-ever study in which these Chi/GO beads have been utilized as a drug carrier for the oral drug delivery of metronidazole (MTD) drug, and investigations were made regarding the release pattern of the MTD drug using these Chi/GO beads as a drug carrier for a prolonged period of 84 h. The MTD is loaded on the surface as well as the cavity of the Chi/GO beads to result in MTD-Chi/GO bionanocomposite beads. The MTD drug loading was found to be 683 mg/g. Furthermore, the in vitro release patterns of pure drug and the drug encapsulated with Chi/GO beads are explored in simulated gastric as well as simulated intestinal fluids with phosphate-buffered saline (PBS) of pH 1.2 and 7.4, respectively. As-synthesized bionanocomposite beads have shown excellent stability and capacity for extended release of the MTD drug as compared to the pure drug in terms of bioavailability in both media. The cumulative release data are fitted with the
Identifiants
pubmed: 34395991
doi: 10.1021/acsomega.1c02422
pmc: PMC8359167
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20433-20444Informations de copyright
© 2021 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Glob Chall. 2019 Aug 14;3(10):1900002
pubmed: 31592120
J Colloid Interface Sci. 2008 Jun 1;322(1):321-6
pubmed: 18402973
Nat Commun. 2018 Jul 17;9(1):2784
pubmed: 30018305
ACS Nano. 2010 Aug 24;4(8):4806-14
pubmed: 20731455
Profiles Drug Subst Excip Relat Methodol. 2009;34:115-51
pubmed: 22469173
Carbohydr Polym. 2014 Dec 19;114:246-252
pubmed: 25263888
J Control Release. 2014 Jan 10;173:75-88
pubmed: 24161530
ACS Omega. 2018 Nov 30;3(11):16377-16385
pubmed: 31458273
J Food Sci Technol. 2018 Mar;55(3):899-904
pubmed: 29487431
J Control Release. 2018 Sep 28;286:64-73
pubmed: 30031155
Pharmaceuticals (Basel). 2017 Dec 12;10(4):
pubmed: 29231857
Biomacromolecules. 2018 Apr 9;19(4):1294-1304
pubmed: 29537830
Colloids Surf B Biointerfaces. 2014 Oct 1;122:332-340
pubmed: 25064484
J Nanosci Nanotechnol. 2017 Apr;17(4):2508-514
pubmed: 29648775
J Agric Food Chem. 2020 Aug 12;68(32):8710-8719
pubmed: 32633505
J Control Release. 2014 Sep 28;190:31-2
pubmed: 25356469
Can J Gastroenterol Hepatol. 2018 Dec 2;2018:4601420
pubmed: 30631758
Small. 2011 Jun 6;7(11):1569-78
pubmed: 21538871
Int J Biol Macromol. 2014 Apr;65:534-41
pubmed: 24530323
Int J Biol Macromol. 2018 May;111:62-69
pubmed: 29292143
Nano Res. 2008;1(3):203-212
pubmed: 20216934
Carbohydr Polym. 2017 Nov 1;175:509-517
pubmed: 28917895
Acta Pol Pharm. 2010 May-Jun;67(3):217-23
pubmed: 20524422
Int J Biol Macromol. 2015 Feb;73:109-14
pubmed: 25605426
J Food Drug Anal. 2015 Dec;23(4):619-629
pubmed: 28911477
Carbohydr Polym. 2019 Sep 1;219:405-413
pubmed: 31151541
Carbohydr Polym. 2016 Jun 25;144:140-8
pubmed: 27083803
Chem Cent J. 2013 Feb 25;7(1):39
pubmed: 23442350
Polymers (Basel). 2020 Apr 01;12(4):
pubmed: 32244671
Carbohydr Polym. 2017 Nov 15;176:315-326
pubmed: 28927614
Nano Res. 2009 Feb 1;2(2):85-120
pubmed: 20174481
J Control Release. 2018 Oct 10;287:235-246
pubmed: 30107214
Ultrason Sonochem. 2016 Sep;32:300-306
pubmed: 27150774
J Colloid Interface Sci. 2018 Mar 1;513:700-714
pubmed: 29216578
J Hazard Mater. 2013 Jan 15;244-245:29-38
pubmed: 23270947
J Biomater Appl. 2008 Jul;23(1):5-36
pubmed: 18593819
Int J Biol Macromol. 2007 Feb 20;40(3):175-81
pubmed: 16893564
Carbohydr Polym. 2017 Jan 2;155:507-515
pubmed: 27702542
Int J Pharm. 2016 Jul 25;509(1-2):400-407
pubmed: 27286635
ACS Omega. 2018 Dec 17;3(12):17416-17424
pubmed: 31458347
J Am Chem Soc. 2008 Aug 20;130(33):10876-7
pubmed: 18661992
ACS Omega. 2021 Mar 30;6(14):9587-9599
pubmed: 33869939
J Drug Target. 1994;2(3):241-57
pubmed: 7812693
Int J Biol Macromol. 2013 Jun;57:193-203
pubmed: 23518244
Carbohydr Polym. 2018 Dec 1;201:264-279
pubmed: 30241819
Dalton Trans. 2020 Feb 11;49(6):1963-1974
pubmed: 31984397