Alkylation of rabbit muscle creatine kinase surface methionine residues inhibits enzyme activity in vitro.
Alkylating agents
Enzyme activity
Free cysteine residue
Hydroxyethylthioethyl
Mass spectrometry
Methionine
Sulfur mustard
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
09
07
2021
accepted:
11
08
2021
pubmed:
17
8
2021
medline:
29
1
2022
entrez:
16
8
2021
Statut:
ppublish
Résumé
Creatine kinase (CK) catalyzes the formation of phosphocreatine from adenosine triphosphate (ATP) and creatine. The highly reactive free cysteine residue in the active site of the enzyme (Cys
Identifiants
pubmed: 34396457
doi: 10.1007/s00204-021-03137-6
pii: 10.1007/s00204-021-03137-6
pmc: PMC8448711
doi:
Substances chimiques
Chemical Warfare Agents
0
Methionine
AE28F7PNPL
Creatine Kinase, MM Form
EC 2.7.3.2
Cysteine
K848JZ4886
Mustard Gas
T8KEC9FH9P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3253-3261Informations de copyright
© 2021. The Author(s).
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