A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action.
American ginseng
Cognition
Gut microbiome
Mood
SCFA
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
26
11
2020
accepted:
04
08
2021
pubmed:
17
8
2021
medline:
27
1
2022
entrez:
16
8
2021
Statut:
ppublish
Résumé
Cereboost®, an American ginseng extract, has shown improved short-term memory and attention/alertness in healthy young and middle-aged individuals, potentially via modulation of the gut microbiome and upregulation of neurotransmitters such as acetylcholine. Here, we explored the effects of Cereboost® on cognition and mood in the first 6 h post intervention (acute), after 2 weeks daily supplementation (chronic), and whether 2 weeks daily supplementation altered the response to a single acute dose (acute-on-chronic). A concurrent in vitro study evaluated effects of repeated Cereboost® administration on human gut microbiota. Cognitive effects of Cereboost® were assessed using a double-blind, randomized, placebo-controlled clinical trial, with 61 healthy young adults. Modulation of the gut microbiome was concurrently modelled using the Simulator of the Human Microbial Ecosystem (SHIME®), using a young adult donor. Consistent with previous findings, Cereboost® improved working memory and attention during the immediate postprandial period; effects that were amplified following two weeks' treatment (acute-on-chronic) compared to acute testing alone. Chronic supplementation improved cognition on an acetylcholine-sensitive attention task and improved mental fatigue and self-assurance aspects of mood. The parallel in vitro study revealed significantly increased acetate, propionate, and butyrate levels in simulated proximal and distal colon regions, linked with observed increases in Akkermansia muciniphila and Lactobacillus. This study confirmed the promising effects of Cereboost® on cognitive function and mood, while suggesting a possible link to alterations of the gut microbiome and modulation of acetylcholine. Further studies will be required to unravel the underlying mechanisms that are involved. The study was pre-registered at ClinicalTrials.gov on 6th July 2018 (Identifier: NCT03579095).
Identifiants
pubmed: 34396468
doi: 10.1007/s00394-021-02654-5
pii: 10.1007/s00394-021-02654-5
pmc: PMC8783888
doi:
Substances chimiques
Cereboost
0
Plant Extracts
0
Banques de données
ClinicalTrials.gov
['NCT03579095']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
413-428Subventions
Organisme : Naturex SA
ID : 0
Informations de copyright
© 2021. The Author(s).
Références
Am J Chin Med. 2011;39(6):1161-71
pubmed: 22083988
Lett Appl Microbiol. 2008 Nov;47(5):367-73
pubmed: 19146523
Curr Neuropharmacol. 2016;14(1):101-15
pubmed: 26813123
Am J Clin Nutr. 2001 Apr;73(4):753-8
pubmed: 11273850
Nutrients. 2018 May 23;10(6):
pubmed: 29882843
Brain Res Mol Brain Res. 1997 Jul;47(1-2):177-82
pubmed: 9221915
Br J Clin Pharmacol. 2013 Mar;75(3):728-37
pubmed: 23043278
Pharmacology. 1991;42(4):223-9
pubmed: 1852782
Phytomedicine. 2000 Apr;7(2):85-9
pubmed: 10839209
J Psychopharmacol. 2006 Nov;20(6):771-81
pubmed: 16401645
Psychopharmacology (Berl). 1984;82(3):147-50
pubmed: 6425892
Food Funct. 2017 Nov 15;8(11):4129-4138
pubmed: 29026903
Nutr Rev. 2014 May;72(5):319-33
pubmed: 24666107
J Gerontol A Biol Sci Med Sci. 2020 Jun 18;75(7):1242-1250
pubmed: 31811292
Nutr Healthy Aging. 2018 Jun 15;4(4):309-322
pubmed: 29951591
Psychol Bull. 2019 Aug;145(8):785-821
pubmed: 31180695
J Ginseng Res. 2013 Oct;37(4):451-6
pubmed: 24235859
Appl Environ Microbiol. 2007 Dec;73(23):7767-70
pubmed: 17933936
Arch Intern Med. 2000 Apr 10;160(7):1009-13
pubmed: 10761967
J Ginseng Res. 2014 Apr;38(2):106-15
pubmed: 24748834
Hum Psychopharmacol. 2015 Mar;30(2):108-22
pubmed: 25778987
FEMS Microbiol Ecol. 2010 Dec;74(3):601-11
pubmed: 20946352
Appl Environ Microbiol. 2003 Mar;69(3):1511-20
pubmed: 12620837
J Nat Prod. 1987 Mar-Apr;50(2):188-90
pubmed: 3655794
Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209
pubmed: 25830558
J Pers Soc Psychol. 1988 Jun;54(6):1063-70
pubmed: 3397865
Microb Biotechnol. 2012 Jan;5(1):106-15
pubmed: 21989255
Regul Toxicol Pharmacol. 2016 Jul;78:53-8
pubmed: 27112419
Eur J Nutr. 2018 Apr;57(3):1169-1180
pubmed: 28283823
Nat Rev Gastroenterol Hepatol. 2019 Aug;16(8):461-478
pubmed: 31123355
Hum Psychopharmacol. 2020 Nov;35(6):1-6
pubmed: 32896022
Acta Pharmacol Sin. 2008 Sep;29(9):1103-8
pubmed: 18718179
Neuropsychopharmacology. 2011 Jan;36(1):52-73
pubmed: 20668433
Curr Med Chem. 2009;16(22):2924-42
pubmed: 19689273
Phytomedicine. 2000 Oct;7(5):365-71
pubmed: 11081987
J Appl Microbiol. 2004;97(6):1166-77
pubmed: 15546407
J Am Coll Nutr. 2000 Nov-Dec;19(6):738-44
pubmed: 11194526
Curr Neuropharmacol. 2015 Jan;13(1):71-88
pubmed: 26074744
Int J Epidemiol. 2008 Oct;37(5):978-87
pubmed: 18579574
J Psychiatry Neurosci. 1999 Nov;24(5):442-52
pubmed: 10586535
Food Funct. 2016 Apr;7(4):1788-96
pubmed: 26757793
Prev Nutr Food Sci. 2016 Sep;21(3):263-270
pubmed: 27752503
Gut. 1981 Sep;22(9):763-79
pubmed: 7028579
BMJ Open. 2014 Mar 27;4(3):e004503
pubmed: 24674997
Nutrients. 2019 Nov 22;11(12):
pubmed: 31766592
Biomed Chromatogr. 2017 Apr;31(4):
pubmed: 27606833
Philos Trans R Soc Lond B Biol Sci. 2018 Sep 26;373(1756):
pubmed: 30104431
FEMS Microbiol Ecol. 2009 Jun;68(3):351-62
pubmed: 19302550
Cancer Prev Res (Phila). 2016 Oct;9(10):803-811
pubmed: 27443884
Food Funct. 2016 Nov 9;7(11):4506-4515
pubmed: 27801453
J Pharmacol Sci. 2004 Jun;95(2):153-7
pubmed: 15215638
FEMS Microbiol Ecol. 2004 Sep 1;49(3):495-507
pubmed: 19712298
J Psychopharmacol. 2010 Oct;24(10):1505-14
pubmed: 19942640
Appl Microbiol Biotechnol. 1993 May;39(2):254-8
pubmed: 7763732
Nutr Rev. 2001 Apr;59(4):91-102
pubmed: 11368507
Psychopharmacology (Berl). 2010 Oct;212(3):345-56
pubmed: 20676609