Developmental screening of three-year-old children with sickle cell disease compared to controls.
Anemia, Sickle Cell
/ complications
Antisickling Agents
/ therapeutic use
Child, Preschool
Family Characteristics
Female
Humans
Hydroxyurea
/ therapeutic use
Income
Male
Mass Screening
Neurodevelopmental Disorders
/ diagnosis
Neuropsychological Tests
Prospective Studies
Social Determinants of Health
Brigance
cognition
development
screening
sickle cell disease
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
13
07
2021
received:
29
04
2021
accepted:
02
08
2021
pubmed:
17
8
2021
medline:
24
12
2021
entrez:
16
8
2021
Statut:
ppublish
Résumé
We previously found that neurodevelopmental deficits commonly occurred in three-year-olds with sickle cell disease (SCD), but clinical significance was uncertain because a comparison group was lacking. Our objective in the current study was to prospectively compare neurodevelopment in three-year-old children with SCD to an age-appropriate control group. The Brigance Preschool Screen II is a neurodevelopmental screening examination which can be administered in 15-20 min. SCD patients (Group 1) were compared with community controls of similar age and ethnicity enrolled in daycare/preschool (Group 2). SCD patients who were receiving hydroxycarbamide treatment were also compared (Group 3). Two hundred forty-five three-year-olds were evaluated: Group 1, 111; Group 2, 114; and Group 3, 20. The below cut-off rate on the Brigance test was higher in Group 1 (73%) than in Group 2 (61%; P = 0·04). In multivariate analysis of Group 1 patients, only lower household income and more persons living in the home were independent predictors of this. Patients with SCD and matched controls had high rates of 'failing' the Brigance test. The below cut-off rate in untreated children with SCD was associated with low household income and increased number of persons living in the home.
Substances chimiques
Antisickling Agents
0
Hydroxyurea
X6Q56QN5QC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
621-628Informations de copyright
© 2021 British Society for Haematology and John Wiley & Sons Ltd.
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