Clinical Pharmacology of Electronic Nicotine Delivery Systems (ENDS): Implications for Benefits and Risks in the Promotion of the Combusted Tobacco Endgame.
Area Under Curve
Brain
/ drug effects
Electronic Nicotine Delivery Systems
Humans
Metabolic Clearance Rate
Nicotine
/ chemistry
Prevalence
Smoking Cessation
/ methods
Nicotiana
/ adverse effects
Tobacco Use Disorder
/ physiopathology
United States
/ epidemiology
United States Food and Drug Administration
e-cigarettes
electronic nicotine delivery
heat-not-burn
nicotine
tobacco
Journal
Journal of clinical pharmacology
ISSN: 1552-4604
Titre abrégé: J Clin Pharmacol
Pays: England
ID NLM: 0366372
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
15
03
2021
accepted:
22
05
2021
entrez:
16
8
2021
pubmed:
17
8
2021
medline:
28
1
2022
Statut:
ppublish
Résumé
Electronic nicotine delivery systems (ENDS) such as e-cigarettes and heated tobacco products are novel battery-operated devices that deliver nicotine without combustion of tobacco. Because cigarette smoking is sustained by nicotine addiction and the toxic combustion products are mainly responsible for the harmful effects of smoking, ENDS could be used to promote smoking cessation while exposing users to lower levels of toxicants compared with conventional cigarettes. The currently available evidence from clinical and observational studies indicates a potential role of e-cigarettes as smoking cessation aids, although many continue to use e-cigarettes long after quitting smoking. Nicotine and toxicant delivery vary considerably by device and depend on the characteristics of the e-liquid formulation. Because smokers tend to titrate their nicotine intake to maintain their desired pharmacologic effects, device and liquid characteristics need to be considered when using ENDS as an aid to quit smoking. Factors potentially limiting their use are the currently still unknown long-term safety of these products and concerns regarding widespread use among youth. Implications of clinical pharmacology data on ENDS for the cigarette endgame and regulation by the U.S. Food and Drug administration are discussed.
Identifiants
pubmed: 34396553
doi: 10.1002/jcph.1915
pmc: PMC9239851
mid: NIHMS1818157
doi:
Substances chimiques
Nicotine
6M3C89ZY6R
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
S18-S36Subventions
Organisme : NIH HHS
ID : U54HL147127
Pays : United States
Organisme : NCRR NIH HHS
ID : RR 024131
Pays : United States
Organisme : NCRR NIH HHS
ID : NIH/NCRR UL1 RR024131
Pays : United States
Organisme : NHLBI NIH HHS
ID : U54 HL147127
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024131
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA039264
Pays : United States
Organisme : NHLBI NIH HHS
ID : HL 147127
Pays : United States
Informations de copyright
© 2021, The American College of Clinical Pharmacology.
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