Clinicopathological features of nodular gastritis in three classes of age.
classes of age
inflammation
nodular gastritis
pangastritis
updated Sydney System score
Journal
Helicobacter
ISSN: 1523-5378
Titre abrégé: Helicobacter
Pays: England
ID NLM: 9605411
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
revised:
29
07
2021
received:
01
07
2021
accepted:
03
08
2021
pubmed:
17
8
2021
medline:
16
11
2021
entrez:
16
8
2021
Statut:
ppublish
Résumé
Nodular gastritis is most often one of the manifestations of Helicobacter pylori (H. pylori) infection, which is a risk factor for gastric cancer. This study aimed to determine if the histological characteristics of nodular gastritis differed across classes of age. We conducted a retrospective analysis of consecutive patients who had undergone esophagogastroduodenoscopy with multiple mucosal biopsies of the stomach between 2003 and 2019 for evaluation of updated Sydney System scores. We analyzed and compared the histological characteristics of pediatric (≤15 years old), young (16-29 years old), and older (≥30 years old) patients. Of the 1321 patients enrolled, 1027 patients (78%) had H. pylori infection, with 214 patients (21%) of them displaying nodular gastritis. Among nodular gastritis patients, mononuclear cell infiltration Sydney System scores in the gastric body were significantly higher in the older group than in the pediatric (p < .001) and young (p < .001) groups. Similar results were seen for neutrophil infiltration scores in the gastric body. To clarify the characteristics of older nodular gastritis, we investigated 1056 older patients (66 with nodular gastritis, 754 with atrophic gastritis, and 236 H. pylori-negative). The scores for mononuclear and neutrophil cell infiltration in the gastric body were significantly higher in nodular gastritis patients than in atrophic gastritis patients (both p < .001) and patients negative for H. pylori (both p < .001). The inflammatory changes in the gastric body in older nodular gastritis patients were more severe as compared with those in pediatric and young nodular gastritis patients in addition to older atrophic gastritis patients.
Sections du résumé
BACKGROUND
BACKGROUND
Nodular gastritis is most often one of the manifestations of Helicobacter pylori (H. pylori) infection, which is a risk factor for gastric cancer. This study aimed to determine if the histological characteristics of nodular gastritis differed across classes of age.
METHODS
METHODS
We conducted a retrospective analysis of consecutive patients who had undergone esophagogastroduodenoscopy with multiple mucosal biopsies of the stomach between 2003 and 2019 for evaluation of updated Sydney System scores. We analyzed and compared the histological characteristics of pediatric (≤15 years old), young (16-29 years old), and older (≥30 years old) patients.
RESULTS
RESULTS
Of the 1321 patients enrolled, 1027 patients (78%) had H. pylori infection, with 214 patients (21%) of them displaying nodular gastritis. Among nodular gastritis patients, mononuclear cell infiltration Sydney System scores in the gastric body were significantly higher in the older group than in the pediatric (p < .001) and young (p < .001) groups. Similar results were seen for neutrophil infiltration scores in the gastric body. To clarify the characteristics of older nodular gastritis, we investigated 1056 older patients (66 with nodular gastritis, 754 with atrophic gastritis, and 236 H. pylori-negative). The scores for mononuclear and neutrophil cell infiltration in the gastric body were significantly higher in nodular gastritis patients than in atrophic gastritis patients (both p < .001) and patients negative for H. pylori (both p < .001).
CONCLUSIONS
CONCLUSIONS
The inflammatory changes in the gastric body in older nodular gastritis patients were more severe as compared with those in pediatric and young nodular gastritis patients in addition to older atrophic gastritis patients.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12845Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
Malfertheiner P, Megraud F, O'Morain CA, et al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017;66(1):6-30.
Miyamoto M, Haruma K, Yoshihara M, et al. Nodular gastritis in adults is caused by Helicobacter pylori infection. Dig Dis Sci. 2003;48(5):968-975.
Nishikawa I, Kato J, Terasoma S, et al. Nodular gastritis in association with gastric cancer development before and after Helicobacter pylori eradication. JGH Open. 2018;2(3):80-86.
Sbeih F, Abdullah A, Sullivan S, Merenkov Z. Antral nodularity, gastric lymphoid hyperplasia, and Helicobacter pylori in adults. J Clin Gastroenterol. 1996;22(3):227-230.
Kamada T, Tanaka A, Yamanaka Y, et al. Nodular gastritis with Helicobacter Pylori infection is strongly associated with diffuse-type gastric cancer in young patients. Dig Endosc. 2007;19(4):180-184.
Hirahashi M, Yao T, Matsumoto T, et al. Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia. Mod Pathol. 2007;20(1):29-34.
Akamatsu T, Okamura T, Iwaya Y, Suga T. Screening to identify and eradicate Helicobacter pylori infection in teenagers in Japan. Gastroenterol Clin North Am. 2015;44(3):667-676.
Honma H, Nakayama Y, Kato S, et al. Clinical features of Helicobacter pylori antibody-positive junior high school students in Nagano Prefecture, Japan. Helicobacter. 2019;24(2):e12559.
Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. Am J Surg Pathol. 1996;20(10):1161-1181.
Eastham EJ, Elliott TS, Berkeley D, Jones DM. Campylobacter pylori infection in children. J Infect. 1988;16(1):77-79.
Shiotani A, Kamada T, Kumamoto M, et al. Nodular gastritis in Japanese young adults: endoscopic and histological observations. J Gastroenterol. 2007;42(8):610-615.
Kimura K, Takemoto T. An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy. 1969;1(3):87-97.
Conti-Nibali S, Sferlazzas C, Fera MT, Saitta G, Tedeschi A, Magazzù G. Helicobacter pylori infection: a simplified diagnostic approach. Am J Gastroenterol. 1990;85(12):1573-1575.
Niknam R, Manafi A, Maghbool M, Kouhpayeh A, Mahmoudi L. Is endoscopic nodular gastritis associated with premalignant lesions? Neth J Med. 2015;73(5):236-241.
Bahú Mda G, da Silveira TR, Maguilnick I, Ulbrich-Kulczynski J. Endoscopic nodular gastritis: an endoscopic indicator of high-grade bacterial colonization and severe gastritis in children with Helicobacter pylori. J Pediatr Gastroenterol Nutr. 2003;36(2):217-222.
Watanabe M, Kato J, Inoue I, et al. Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis. Int J Cancer. 2012;131(11):2632-2642.
Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345(11):784-789.
Arisawa T, Tahara T, Shiroeda H, et al. Functional promoter polymorphisms of NFKB1 influence susceptibility to the diffuse type of gastric cancer. Oncol Rep. 2013;30(6):3013-3019.
Haruma K, Kato M, Inoue K, Murakami K. Kyoto Classification of Gastritis. :Nihon Medical Center; 2017.
Uchida K, Okazaki K, Debrecceni A, et al. Analysis of cytokines in the early development of gastric secondary lymphoid follicles in Helicobacter pylori-infected BALB/c mice with neonatal thymectomy. Infect Immun. 2001;69(11):6749-6754.
Freire de Melo F, Rocha GA, Rocha AM, et al. Th1 immune response to H. pylori infection varies according to the age of the patients and influences the gastric inflammatory patterns. Int J Med Microbiol. 2014;304(3-4):300-306.