The Circadian Clock, the Brain, and COVID-19: The Cases of Olfaction and the Timing of Sleep.


Journal

Journal of biological rhythms
ISSN: 1552-4531
Titre abrégé: J Biol Rhythms
Pays: United States
ID NLM: 8700115

Informations de publication

Date de publication:
10 2021
Historique:
pubmed: 17 8 2021
medline: 18 9 2021
entrez: 16 8 2021
Statut: ppublish

Résumé

Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptoms displayed by many COVID-19 patients. Motivated by the relatively unexplored, yet pervasive, overlap between circadian functions and COVID-19 neurological symptoms, this perspective piece uses daily variations in the sense of smell and the timing of sleep and wakefulness as illustrative examples. We propose that time-stamping clinical data and testing may expand and refine diagnosis and treatment of COVID-19.

Identifiants

pubmed: 34396817
doi: 10.1177/07487304211031206
pmc: PMC8442129
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

423-431

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Auteurs

Rachel S Herz (RS)

Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, Massachusetts, USA.

Erik D Herzog (ED)

Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA.

Martha Merrow (M)

Institute of Medical Psychology, Faculty of Medicine, Ludwig Maximilian University of Munich, Munich, Germany.

Sara B Noya (SB)

Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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Classifications MeSH