Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping.
cerebellum
chicken
developmental biology
interneurons
locomotion
neural circuits
neuroscience
spinal cord
spinocerebellar tract
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
16 08 2021
16 08 2021
Historique:
received:
11
08
2020
accepted:
11
08
2021
pubmed:
17
8
2021
medline:
30
11
2021
entrez:
16
8
2021
Statut:
epublish
Résumé
Peripheral and intraspinal feedback is required to shape and update the output of spinal networks that execute motor behavior. We report that lumbar dI2 spinal interneurons in chicks receive synaptic input from afferents and premotor neurons. These interneurons innervate contralateral premotor networks in the lumbar and brachial spinal cord, and their ascending projections innervate the cerebellum. These findings suggest that dI2 neurons function as interneurons in local lumbar circuits, are involved in lumbo-brachial coupling, and that part of them deliver peripheral and intraspinal feedback to the cerebellum. Silencing of dI2 neurons leads to destabilized stepping in posthatching day 8 hatchlings, with occasional collapses, variable step profiles, and a wide-base walking gait, suggesting that dI2 neurons may contribute to the stabilization of the bipedal gait.
Identifiants
pubmed: 34396953
doi: 10.7554/eLife.62001
pii: 62001
pmc: PMC8448531
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Haimson et al.
Déclaration de conflit d'intérêts
BH, YH, NB, AK, MD, YC, AL, AK none
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