Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model.

Animals Disease Models, Animal Female Hypoxia-Inducible Factor 1 / biosynthesis Mice Neovascularization, Physiologic Pre-Eclampsia / etiology Pregnancy Vascular Endothelial Growth Factor Receptor-1 / blood Vascular Remodeling / physiology
hypertension mice placenta pregnancy trophoblast

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
09 2021
Historique:
pubmed: 17 8 2021
medline: 14 1 2022
entrez: 16 8 2021
Statut: ppublish

Résumé

[Figure: see text].

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.121.17567 PMID: 34397280 PMC: PMC8415521
pubmed: 34397280
doi: 10.1161/HYPERTENSIONAHA.121.17567
pmc: PMC8415521
doi:

Substances chimiques

Hypoxia-Inducible Factor 1 0
Flt1 protein, mouse EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-1 EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1067-1079

Auteurs

Rebekka Vogtmann (R)

Department of Gynecology and Obstetrics, University Hospital Essen, Germany (R.V., J.H., R.K., A.K., A.G.).
ORCID: 0000-0002-8491-500X

Jacqueline Heupel (J)

Department of Gynecology and Obstetrics, University Hospital Essen, Germany (R.V., J.H., R.K., A.K., A.G.).

Florian Herse (F)

Experimental and Clinical Research Center (ECRC), a cooperation of Charité - Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine (MDC), Berlin, Germany (F.H., K.K., R.D.).
Max Delbruck Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany (F.H., K.K.).

Mahsa Matin (M)

Department II of Internal Medicine-Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine-University Hospital Cologne, Cologne, Germany and Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases, Germany (M.M., H.H.).

Henning Hagmann (H)

Department II of Internal Medicine-Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine-University Hospital Cologne, Cologne, Germany and Cologne Cluster of Excellence on Cellular Stress Responses in Ageing-Associated Diseases, Germany (M.M., H.H.).

Ivo Bendix (I)

Department of Pediatrics I, Neonatology & Experimental Perinatal Neurosciences, University Hospital Essen, University of Duisburg-Essen, Germany (I.B.).
ORCID: 0000-0002-9751-3640

Kristin Kräker (K)

Experimental and Clinical Research Center (ECRC), a cooperation of Charité - Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine (MDC), Berlin, Germany (F.H., K.K., R.D.).
Max Delbruck Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany (F.H., K.K.).
Charité-Universitätsmedizin Berlin and Humboldt-Universität zu Berlin, Berlin, Germany (K.K.).

Ralf Dechend (R)

Experimental and Clinical Research Center (ECRC), a cooperation of Charité - Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine (MDC), Berlin, Germany (F.H., K.K., R.D.).
HELIOS Klinikum, Berlin, Germany (R.D.).

Elke Winterhager (E)

Imaging Center Essen, EM Unit, University Hospital Essen, Germany (E.W.).

Rainer Kimmig (R)

Department of Gynecology and Obstetrics, University Hospital Essen, Germany (R.V., J.H., R.K., A.K., A.G.).

Angela Köninger (A)

Department of Gynecology and Obstetrics, University Hospital Essen, Germany (R.V., J.H., R.K., A.K., A.G.).
Department of Gynecology and Obstetrics, Clinic of the Order of St. John, St. Hedwigs Clinic, Regensburg, Germany (A.K.).

Alexandra Gellhaus (A)

Department of Gynecology and Obstetrics, University Hospital Essen, Germany (R.V., J.H., R.K., A.K., A.G.).
ORCID: 0000-0001-9506-4581

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Circulating Maternal sFLT1 (Soluble fms-Like...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Circulating Maternal sFLT1 (Soluble fms-Like...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteur-1 induit par l'hypoxie › Circulating Maternal sFLT1 (Soluble fms-Like...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Circulating Maternal sFLT1 (Soluble fms-Like...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Néovascularisation physiologique › Circulating Maternal sFLT1 (Soluble fms-Like...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Pré-éclampsie › Circulating Maternal sFLT1 (Soluble fms-Like...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Circulating Maternal sFLT1 (Soluble fms-Like...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance endothéliale vasculaire › Récepteur-1 au facteur croissance endothéliale vasculaire › Circulating Maternal sFLT1 (Soluble fms-Like...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Remodelage vasculaire › Circulating Maternal sFLT1 (Soluble fms-Like...