Clinical study of invasive pulmonary aspergillosis following influenza A H1N1.
Adult
Aged
Aspergillus fumigatus
/ drug effects
Bronchoalveolar Lavage Fluid
Chi-Square Distribution
China
Female
Humans
Influenza A Virus, H1N1 Subtype
/ drug effects
Influenza, Human
/ complications
Male
Middle Aged
Prospective Studies
Pulmonary Aspergillosis
/ diagnosis
Retrospective Studies
Tomography, X-Ray Computed
/ methods
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
30 Jul 2021
30 Jul 2021
Historique:
received:
28
10
2019
accepted:
04
06
2021
entrez:
16
8
2021
pubmed:
17
8
2021
medline:
25
8
2021
Statut:
ppublish
Résumé
This study to analyze the clinical characteristics of patients with invasive pulmonary aspergillosis (IPA) following influenza A (H1N1) infection.We retrospectively analyzed 10 cases with IPA following H1N1 infection. The clinical manifestations, laboratory examination results, chest computed tomography, and treatments were analyzed.Clinical manifestations: all 10 cases had typical flu-like symptoms at the onset of the disease, among which 7 patients developed dyspnea in the late stage, and 8 patients had hemoptysis. Laboratory examination: the absolute and percentage of peripheral blood lymphocytes in all 10 patients were declined, among which 5 cases were with decreased CD3+ CD4+ T cells/lymphocytes; 9 cases with increased bronchoalveolar lavage fluid galactomannan; 6 cases with increased serum galactomannan; 1 case with bronchoalveolar lavage fluid cultured aspergillus fumigatus; and 2 cases with aspergillus by second-generation sequencing. Chest computed tomography: all patients showed multiple diffused ground-glass opacities at the beginning, along with linear or reticular interstitial changes. Two cases had multiple subarachnoid nodules with halo signs, 3 cases had consolidation in multiple segments of both lungs, 2 cases had cavities, and 4 cases were with pleural effusion. Treatment: 10 patients were treated with antiviral and anti-Aspergillus drugs after admission. Four patients received respiratory support. All 10 cases were cured and discharged.Early diagnosis of IPA in influenza A (H1N1) patients is the key to successful treatment.
Identifiants
pubmed: 34397685
doi: 10.1097/MD.0000000000026434
pii: 00005792-202107300-00006
pmc: PMC8322502
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e26434Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
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