Two Medicinal Plants (Alkanna trichophila and Convolvulus galaticus) from Turkey: Chemical Characterization and Biological Perspectives.
Acetylcholinesterase
/ metabolism
Agaricales
/ enzymology
Antioxidants
/ chemistry
Benzothiazoles
/ antagonists & inhibitors
Biphenyl Compounds
/ antagonists & inhibitors
Boraginaceae
/ chemistry
Butyrylcholinesterase
/ metabolism
Convolvulus
/ chemistry
Enzyme Inhibitors
/ chemistry
Humans
Monophenol Monooxygenase
/ antagonists & inhibitors
Picrates
/ antagonists & inhibitors
Plant Extracts
/ chemistry
Plants, Medicinal
/ chemistry
Saccharomyces cerevisiae
/ enzymology
Sulfonic Acids
/ antagonists & inhibitors
Turkey
alpha-Amylases
/ antagonists & inhibitors
HPLC-MS/MS
Medicinal plants
antioxidants
caffeoylquinic acid derivatives
enzymes
herbal medicine
rutin
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
04
05
2021
accepted:
16
08
2021
pubmed:
17
8
2021
medline:
15
12
2021
entrez:
16
8
2021
Statut:
ppublish
Résumé
The aim of the present study was to quantify selected phenolic compounds, determine antioxidant activity and enzyme inhibitory effects of the aerial parts of Alkanna trichophylla Hub.-Mor. (A. trichophylla) and Convolvulus galaticus Rost.ex Choisy (C. galaticus) extracts prepared by homogenizer-assisted extraction (HAE), maceration (MAC) and infusion techniques. This is the first time such study has been designed to validate the phytochemical composition and bioactivity of these plants. Multivariate analysis was conducted on collected data. Rutin and caffeoylquinic acid derivatives were the most significant compounds in A. trichophylla and C. galaticus, respectively. The highest antioxidant activity of A. trichophylla was mostly exhibited by HAE/methanolic extracts as determined by DPPH, ABTS, FRAP (51.39, 112.70 and 145.73 mg TE/g, respectively) and phosphomolybdenum (2.05 mmol TE/g) assays. However, significant antioxidant activities varied within the extracts of C. galaticus. HAE/methanolic extract of A. trichophylla significantly depressed AChE (2.70 mg GALAE/g), BChE (5.53 mg GALAE/g) and tyrosinase (26.34 mg KAE/g) activities and that of C. galaticus inhibited AChE (2.04 mg GALAE/g), tyrosinase (31.25 mg KAE/g) and α-amylase (0.53 mmol ACAE/g) activities significantly. We concluded that HAE was the most efficient extraction technique as high yield of compounds and promising bioactivities were recorded from extracts prepared. Multivariate analysis showed that types of solvents influenced recovery of compounds and biological activities. This research study can be used as one methodological starting point for further investigation on these plants as all results are clearly promising and open the door to further research challenges such as cytotoxicity evaluation, molecular docking analysis, and more screening of pharmacological actions.
Identifiants
pubmed: 34398524
doi: 10.1002/cbdv.202100356
doi:
Substances chimiques
Antioxidants
0
Benzothiazoles
0
Biphenyl Compounds
0
Enzyme Inhibitors
0
Picrates
0
Plant Extracts
0
Sulfonic Acids
0
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
28752-68-3
1,1-diphenyl-2-picrylhydrazyl
DFD3H4VGDH
Monophenol Monooxygenase
EC 1.14.18.1
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
alpha-Amylases
EC 3.2.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100356Informations de copyright
© 2021 Wiley-VHCA AG, Zurich, Switzerland.
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