Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer.

Humans Hydrogels Neoplasms / drug therapy Reactive Oxygen Species
Plasma-activated biogel Post-operative tumor treatment Reactive oxygen species Surface discharge plasma

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
09 2021
Historique:
received: 23 03 2021
revised: 14 07 2021
accepted: 04 08 2021
pubmed: 17 8 2021
medline: 21 9 2021
entrez: 16 8 2021
Statut: ppublish

Résumé

Post-surgical residual tumor cells are the primary cause of relapse and progression of cancer but unfortunately, there are limited therapeutic options. In this work, a fillable plasma-activated biogel is produced on a thermosensitive biogel [(Poly-DL-lactide)-(poly-ethylene glycol)-(poly-DL-lactide), PLEL] with the aid of a discharge plasma for local post-operative treatment of cancer. In vivo data show that the plasma-activated PLEL biogel (PAPB) eliminates residual tumor tissues after removal surgery and also inhibits in situ recurrence while showing no evident systemic toxicity. Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effects in vitro. Our results reveal that the novel plasma-activated biogel is an effective therapeutic agent for local post-operative treatment of cancer.

Identifiants

DOI: 10.1016/j.biomaterials.2021.121057 PMID: 34399120
pubmed: 34399120
pii: S0142-9612(21)00413-0
doi: 10.1016/j.biomaterials.2021.121057
pii:
doi:

Substances chimiques

Hydrogels 0
Reactive Oxygen Species 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

121057

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Hao Zhang (H)

State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.

Shengduo Xu (S)

State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.

Jishen Zhang (J)

State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.

Zifeng Wang (Z)

State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.

Dingxin Liu (D)

State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China. Electronic address: liudingxin@mail.xjtu.edu.cn.

Li Guo (L)

State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.

Cheng Cheng (C)

Institute of Plasma Physics, Chinese Academy of Sciences, P. O. Box 1126, Hefei, Anhui, 230031, PR China; Department of Physics, Department of Materials Science and Engineering, And Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.

Yilong Cheng (Y)

Department of Applied Physics, School of Science, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.

Dehui Xu (D)

State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.

Michael G Kong (MG)

State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China; Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA, 23529, USA.

Mingzhe Rong (M)

State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, PR China.

Paul K Chu (PK)

Department of Physics, Department of Materials Science and Engineering, And Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Plasma-activated thermosensitive biogel as an...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Plasma-activated thermosensitive biogel as an...
questionsmedicales.fr › Tumeurs › Plasma-activated thermosensitive biogel as an...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Plasma-activated thermosensitive biogel as an...