Novel insight into biological activity and phytochemical composition of Sorbus aucuparia L. fruits: Fractionated extracts as inhibitors of protein glycation and oxidative/nitrative damage of human plasma components.
Free radicals
Human plasma
Lipid oxidation
Polyphenols
Protein glycation
Protein nitration
Sorbus aucuparia
Journal
Food research international (Ottawa, Ont.)
ISSN: 1873-7145
Titre abrégé: Food Res Int
Pays: Canada
ID NLM: 9210143
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
17
03
2021
revised:
01
06
2021
accepted:
11
06
2021
entrez:
17
8
2021
pubmed:
18
8
2021
medline:
7
9
2021
Statut:
ppublish
Résumé
Sorbus aucuparia L. is a source of edible fruits appreciated for their nutritional and medicinal properties. In this work some bioactivity mechanisms were evaluated, which might be connected with the traditional application of rowanberries in cardiovascular complications of diabetes. With the use of a panel of chemical and biological in vitro models the rowanberry extracts were proved to significantly inhibit the formation of advanced glycation end products, neutralise multiple oxidants generated in vivo, increase the non-enzymatic antioxidant capacity of human plasma and protect plasma components (proteins and lipids) against oxidative/nitrative damage at in vivo-relevant levels (1-5 µg/mL). Moreover, the extracts were found safe in cytotoxicity tests on the peripheral blood mononuclear cells. The comprehensive phytochemical profiling of the extracts (RP/HILIC-UHPLC-PDA-ESI-MS
Identifiants
pubmed: 34399504
pii: S0963-9969(21)00425-7
doi: 10.1016/j.foodres.2021.110526
pii:
doi:
Substances chimiques
Phytochemicals
0
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110526Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.