Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300.

Animals COVID-19 / pathology Chiroptera / virology Coronavirus 3C Proteases / antagonists & inhibitors Cysteine / chemistry Dimerization Glutaredoxins / metabolism Glutathione / chemistry Humans Protein Multimerization SARS-CoV-2 / enzymology
COVID-19 SARS-CoV-2 dimerization drug targets glutaredoxin glutathionylation main protease oxidative stress thioltransferase

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
31 08 2021
Historique:
pubmed: 18 8 2021
medline: 15 9 2021
entrez: 17 8 2021
Statut: ppublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for coronavirus disease 2019 (COVID-19), encodes two proteases required for replication. The main protease (M

Identifiants

DOI: 10.1128/mBio.02094-21 PMID: 34399606 PMC: PMC8406260
pubmed: 34399606
doi: 10.1128/mBio.02094-21
pmc: PMC8406260
doi:

Substances chimiques

Glutaredoxins 0
Coronavirus 3C Proteases EC 3.4.22.28
Glutathione GAN16C9B8O
Cysteine K848JZ4886

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0209421

Subventions

Organisme : National Center for Global Health and Medicine (NCGM)
ID : 19A3001
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : 20fk0108257
Organisme : HHS | NIH | National Cancer Institute (NCI)

Commentaires et corrections

Type : UpdateOf

Références

Biochemistry. 2004 Apr 20;43(15):4568-74
pubmed: 15078103
Biochem Biophys Res Commun. 2006 Jan 20;339(3):865-72
pubmed: 16329994
Biochem J. 2000 Mar 1;346 Pt 2:305-11
pubmed: 10677347
J Virol. 1999 Feb;73(2):1156-64
pubmed: 9882317
Expert Opin Ther Pat. 2021 Apr;31(4):309-324
pubmed: 33246378
Biochem J. 2009 Apr 15;419(2):497-506
pubmed: 19149765
J Virol. 2008 May;82(9):4620-9
pubmed: 18305031
Biochem Biophys Res Commun. 2021 Jan 29;538:63-71
pubmed: 33288200
Protein Cell. 2011 Apr;2(4):282-90
pubmed: 21533772
Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jul-Aug;146(1-2):214-220
pubmed: 17257902
Arch Biochem Biophys. 1993 Jul;304(1):163-9
pubmed: 8323281
Cell. 2008 Apr 18;133(2):235-49
pubmed: 18423196
J Biol Chem. 2010 Oct 22;285(43):33154-33164
pubmed: 20729205
Mol Cells. 2008 May 31;25(3):332-46
pubmed: 18483468
Curr Top Med Chem. 2006;6(4):361-76
pubmed: 16611148
Biochemistry. 1996 Feb 20;35(7):2482-8
pubmed: 8652592
Front Mol Biosci. 2020 Dec 04;7:616341
pubmed: 33344509
Protein J. 2020 Dec;39(6):644-656
pubmed: 33106987
Circulation. 2009 Sep 15;120(11 Suppl):S10-5
pubmed: 19752353
Proteins. 2004 Dec 1;57(4):799-803
pubmed: 15476207
Front Immunol. 2020 Jan 24;11:26
pubmed: 32117225
Nat Med. 2020 Apr;26(4):450-452
pubmed: 32284615
J Mol Biol. 2020 May 1;432(10):3309-3325
pubmed: 32320687
J Biol Chem. 1997 Oct 10;272(41):25935-40
pubmed: 9325327
FEBS J. 2010 Mar;277(6):1465-80
pubmed: 20148960
Arch Biochem Biophys. 1994 Aug 15;313(1):71-6
pubmed: 8053689
Science. 2003 Jun 13;300(5626):1763-7
pubmed: 12746549
Cell Stress Chaperones. 2019 Jul;24(4):835-849
pubmed: 31230214
Science. 2020 Apr 24;368(6489):409-412
pubmed: 32198291
J Virol. 2003 Mar;77(5):3319-25
pubmed: 12584357
Biochem Pharmacol. 2008 Jun 1;75(11):2234-44
pubmed: 18395187
PLoS One. 2010 Oct 22;5(10):e13595
pubmed: 21042582
Curr Zool. 2019 Apr;65(2):147-153
pubmed: 30936903
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4170-4
pubmed: 8633035
Methods Enzymol. 2002;348:249-59
pubmed: 11885278
Nat Commun. 2021 Jan 28;12(1):668
pubmed: 33510133
FASEB J. 2009 Feb;23(2):464-72
pubmed: 18845767
J Chem Theory Comput. 2016 Sep 13;12(9):4662-73
pubmed: 27541839
Nature. 2020 Jun;582(7811):289-293
pubmed: 32272481
Antioxid Redox Signal. 2012 Mar 15;16(6):471-5
pubmed: 22136616
J Biol Chem. 1997 Jan 31;272(5):2700-8
pubmed: 9006907
J Biol Chem. 2005 Nov 11;280(45):37481-8
pubmed: 16150732
Science. 2021 May 7;372(6542):642-646
pubmed: 33811162
Bioorg Med Chem. 2021 Jan 1;29:115860
pubmed: 33191083
mBio. 2020 Aug 20;11(4):
pubmed: 32820005
PLoS Pathog. 2010 Jun 03;6(6):e1000930
pubmed: 20532218
Antioxid Redox Signal. 2008 Nov;10(11):1941-88
pubmed: 18774901
Drug Discov Today. 2021 Mar;26(3):804-816
pubmed: 33309533
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14631-6
pubmed: 11724937
Virology. 2006 Sep 15;353(1):155-65
pubmed: 16806387
Crit Rev Biochem Mol Biol. 1991;26(1):1-52
pubmed: 1678690

Auteurs

David A Davis (DA)

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

Haydar Bulut (H)

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

Prabha Shrestha (P)

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

Amulya Yaparla (A)

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

Hannah K Jaeger (HK)

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

Shin-Ichiro Hattori (SI)

Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.

Paul T Wingfield (PT)

National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.

John J Mieyal (JJ)

Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Hiroaki Mitsuya (H)

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.

Robert Yarchoan (R)

HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Regulation of the Dimerization and Activity of...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Regulation of the Dimerization and Activity of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Chiroptera › Regulation of the Dimerization and Activity of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales non structurales › Protéases virales › Protéases virales 3C › Protéases 3C des coronavirus › Regulation of the Dimerization and Activity of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Regulation of the Dimerization and Activity of...
questionsmedicales.fr › Métabolisme › Dimérisation › Regulation of the Dimerization and Activity of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on sulfur group donors › Glutarédoxines › Regulation of the Dimerization and Activity of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Regulation of the Dimerization and Activity of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Regulation of the Dimerization and Activity of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › Regulation of the Dimerization and Activity of...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Regulation of the Dimerization and Activity of...