Nonmuscle Myosin II in cancer cell migration and mechanotransduction.
Cancer cell motility
Cell migration
Nonmuscle myosin II
Nuclear translocation
Perinuclear actomyosin
Journal
The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
27
02
2021
revised:
16
07
2021
accepted:
11
08
2021
pubmed:
18
8
2021
medline:
17
12
2021
entrez:
17
8
2021
Statut:
ppublish
Résumé
Cell migration is a key step of cancer metastasis, immune-cell navigation, homing of stem cells and development. What adds complexity to it is the heterogeneity of the tissue environment that gives rise to a vast diversity of migratory mechanisms utilized by cells. A majority of cell motility mechanisms reported elsewhere largely converge in depicting the importance of the activity and complexity of actomyosin networks in the cell. In this review, we highlight the less discussed functional diversity of these actomyosin complexes and describe in detail how the major cellular actin-binding molecular motor proteins, nonmuscle myosin IIs are regulated and how they participate and mechanically reciprocate to changes in the microenvironment during cancer cell migration and tumor progression. Understanding the role of nonmuscle myosin IIs in the cancer cell is important for designing efficient therapeutic strategies to prevent cancer metastasis.
Identifiants
pubmed: 34400319
pii: S1357-2725(21)00138-2
doi: 10.1016/j.biocel.2021.106058
pii:
doi:
Substances chimiques
Actomyosin
9013-26-7
Myosin Type II
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106058Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.