Time-dependent transformations of memory representations differ along the long axis of the hippocampus.


Journal

Learning & memory (Cold Spring Harbor, N.Y.)
ISSN: 1549-5485
Titre abrégé: Learn Mem
Pays: United States
ID NLM: 9435678

Informations de publication

Date de publication:
09 2021
Historique:
received: 18 05 2021
accepted: 09 07 2021
entrez: 17 8 2021
pubmed: 18 8 2021
medline: 18 1 2022
Statut: epublish

Résumé

Research has shown that sleep is beneficial for the long-term retention of memories. According to theories of memory consolidation, memories are gradually reorganized, becoming supported by widespread, distributed cortical networks, particularly during postencoding periods of sleep. However, the effects of sleep on the organization of memories in the hippocampus itself remains less clear. In a 3-d study, participants encoded separate lists of word-image pairs differing in their opportunity for sleep-dependent consolidation. Pairs were initially studied either before or after an overnight sleep period, and were then restudied in a functional magnetic resonance imaging (fMRI) scan session. We used multivariate pattern similarity analyses to examine fine-grained effects of consolidation on memory representations in the hippocampus. We provide evidence for a dissociation along the long axis of the hippocampus that emerges with consolidation, such that representational patterns for object-word memories initially formed prior to sleep become differentiated in anterior hippocampus and more similar, or overlapping, in posterior hippocampus. Differentiation in anterior hippocampal representations correlated with subsequent behavioral performance. Furthermore, representational overlap in posterior hippocampus correlated with the duration of intervening slow wave sleep. Together, these results demonstrate that sleep-dependent consolidation promotes the reorganization of memory traces along the long axis of the hippocampus.

Identifiants

pubmed: 34400534
pii: 28/9/329
doi: 10.1101/lm.053438.121
pmc: PMC8372564
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

329-340

Subventions

Organisme : NINDS NIH HHS
ID : K23 NS104252
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH061492
Pays : United States

Informations de copyright

© 2021 Cowan et al.; Published by Cold Spring Harbor Laboratory Press.

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Auteurs

Emily T Cowan (ET)

Temple University, Philadelphia, Pennsylvania 19122, USA.

Anli A Liu (AA)

Comprehensive Epilepsy Center, New York University, New York, New York 10016, USA.
Department of Neurology, New York University Langone Health, New York, New York 10017, USA.

Simon Henin (S)

Comprehensive Epilepsy Center, New York University, New York, New York 10016, USA.
Department of Neurology, New York University Langone Health, New York, New York 10017, USA.

Sanjeev Kothare (S)

Comprehensive Epilepsy Center, New York University, New York, New York 10016, USA.
Department of Neurology, New York University Langone Health, New York, New York 10017, USA.

Orrin Devinsky (O)

Comprehensive Epilepsy Center, New York University, New York, New York 10016, USA.
Department of Neurology, New York University Langone Health, New York, New York 10017, USA.

Lila Davachi (L)

Psychology Department, Columbia University, New York, New York 10027, USA.
Nathan Kline Institute, Orangeburg, New York 10962, USA.

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