Recombinant Annexin A2 Administration Improves Neurological Outcomes After Traumatic Brain Injury in Mice.

Annexin A2 angiogenesis blood-brain barrier cerebrovascular remodeling neurological outcomes traumatic brain injury

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2021
Historique:
received: 12 05 2021
accepted: 28 06 2021
entrez: 17 8 2021
pubmed: 18 8 2021
medline: 18 8 2021
Statut: epublish

Résumé

Microvascular failure is one of the key pathogenic factors in the dynamic pathological evolution after traumatic brain injury (TBI). Our laboratory and others previously reported that Annexin A2 functions in blood-brain barrier (BBB) development and cerebral angiogenesis, and recombinant human Annexin A2 (rA2) protected against hypoxia plus IL-1β-induced cerebral trans-endothelial permeability

Identifiants

DOI: 10.3389/fphar.2021.708469 PMID: 34400908 PMC: PMC8363504
pubmed: 34400908
doi: 10.3389/fphar.2021.708469
pii: 708469
pmc: PMC8363504
doi:

Types de publication

Journal Article

Langues

eng

Pagination

708469

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS092085
Pays : United States

Informations de copyright

Copyright © 2021 Cheng, Wang, Jiang, Li, Liao, Li, Yu, Whalen, Lok, Dumont, Liu and Wang.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

J Neurosci. 2018 Nov 7;38(45):9618-9634
pubmed: 30242049
Biochim Biophys Acta. 2009 Jun;1793(6):1086-95
pubmed: 19022301
Curr Opin Investig Drugs. 2010 Mar;11(3):298-308
pubmed: 20178043
Nat Rev Neurol. 2010 Jul;6(7):393-403
pubmed: 20551947
Neurosurgery. 2011 May;68(5):1363-71; discussion 1371
pubmed: 21307798
J Neurotrauma. 2014 Jan 15;31(2):135-58
pubmed: 23968241
PLoS One. 2016 Jan 21;11(1):e0146886
pubmed: 26796696
Biol Chem. 2016 Oct 1;397(10):1005-16
pubmed: 27366903
Childs Nerv Syst. 2011 Sep;27(9):1465-76
pubmed: 21559825
Br J Pharmacol. 2008 Mar;153 Suppl 1:S396-405
pubmed: 18157168
J Cereb Blood Flow Metab. 2010 Jun;30(6):1137-46
pubmed: 20068577
J Neurosci Res. 2009 Aug 15;87(11):2571-7
pubmed: 19360900
Int J Mol Sci. 2019 Dec 05;20(24):
pubmed: 31817350
Trends Neurosci. 2021 May;44(5):393-405
pubmed: 33423792
Neurosignals. 2011;19(1):16-43
pubmed: 21430360
J Neurotrauma. 2019 Jan 15;36(2):370-379
pubmed: 29768967
J Neurotrauma. 2016 Jul 15;33(14):1303-16
pubmed: 26528928
J Neurosurg. 2010 Sep;113(3):622-9
pubmed: 20035575
J Neurotrauma. 2010 Jan;27(1):121-30
pubmed: 19803784
J Cell Biol. 2015 May 25;209(4):493-506
pubmed: 26008742
J Cereb Blood Flow Metab. 2019 Oct;39(10):2048-2060
pubmed: 29786451
J Cereb Blood Flow Metab. 2017 Jul;37(7):2320-2339
pubmed: 28378621
J Neurosci. 2011 Oct 5;31(40):14346-60
pubmed: 21976520
J Neurosci Res. 2019 Feb;97(2):137-148
pubmed: 30315659
Mol Cell Biochem. 1999 Sep;199(1-2):139-47
pubmed: 10544962
FEBS J. 2009 Sep;276(17):4622-35
pubmed: 19664072
J Biol Chem. 2001 Jul 6;276(27):25184-9
pubmed: 11335727
Commun Biol. 2020 Apr 20;3(1):181
pubmed: 32313072
J Clin Invest. 2009 Nov;119(11):3384-94
pubmed: 19841537
Nat Med. 2016 Nov;22(11):1335-1341
pubmed: 27668935
Front Pharmacol. 2021 Jan 25;11:590669
pubmed: 33568994
Blood. 2011 Sep 8;118(10):2918-29
pubmed: 21788340
Traffic. 2004 Aug;5(8):571-6
pubmed: 15260827
Stroke. 2002 Nov;33(11):2711-7
pubmed: 12411666
Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17622-7
pubmed: 15585582
Neuron. 1998 Apr;20(4):709-26
pubmed: 9581763
Am J Physiol Renal Physiol. 2004 Sep;287(3):F481-91
pubmed: 15113748
Nat Commun. 2019 Sep 17;10(1):4223
pubmed: 31530804
Curr Pharm Des. 2012;18(25):3624-44
pubmed: 22574987
Neuroscience. 2004;125(1):129-39
pubmed: 15051152
Nat Med. 2003 Oct;9(10):1313-7
pubmed: 12960961
J Neuroinflammation. 2019 May 17;16(1):103
pubmed: 31101061
Brain Behav Immun. 2014 Oct;41:10-21
pubmed: 24681251
J Exp Med. 2017 Sep 4;214(9):2535-2545
pubmed: 28694388
Cells. 2020 Jun 19;9(6):
pubmed: 32575495
Int J Cell Biol. 2012;2012:852430
pubmed: 22505935
J Neurotrauma. 2019 Sep 1;36(17):2579-2589
pubmed: 30997843
Cell. 1998 May 29;93(5):661-4
pubmed: 9630209
Cell Commun Signal. 2020 Jul 17;18(1):114
pubmed: 32680529

Auteurs

Chongjie Cheng (C)

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.

Xiaoshu Wang (X)

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.

Yinghua Jiang (Y)

Clinical Neuroscience Research Center, Department of Neurosurgery and Neurology, Tulane University School of Medicine, New Orleans, LA, United States.

Yadan Li (Y)

Clinical Neuroscience Research Center, Department of Neurosurgery and Neurology, Tulane University School of Medicine, New Orleans, LA, United States.

Zhengbu Liao (Z)

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.

Wenlu Li (W)

Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.

Zhanyang Yu (Z)

Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.

Michael J Whalen (MJ)

Department of Pediatrics, Pediatric Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Josephine Lok (J)

Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Department of Pediatrics, Pediatric Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Aaron S Dumont (AS)

Clinical Neuroscience Research Center, Department of Neurosurgery and Neurology, Tulane University School of Medicine, New Orleans, LA, United States.

Ning Liu (N)

Clinical Neuroscience Research Center, Department of Neurosurgery and Neurology, Tulane University School of Medicine, New Orleans, LA, United States.

Xiaoying Wang (X)

Clinical Neuroscience Research Center, Department of Neurosurgery and Neurology, Tulane University School of Medicine, New Orleans, LA, United States.

Classifications MeSH