Head & neck melanoma: A 22-year experience of recurrence following sentinel lymph node biopsy.
head and neck cancer
melanoma
sentinel lymph node
Journal
Laryngoscope investigative otolaryngology
ISSN: 2378-8038
Titre abrégé: Laryngoscope Investig Otolaryngol
Pays: United States
ID NLM: 101684963
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
12
01
2021
revised:
25
03
2021
accepted:
10
06
2021
entrez:
17
8
2021
pubmed:
18
8
2021
medline:
18
8
2021
Statut:
epublish
Résumé
To examine the clinicopathologic factors that contribute to regional and distant recurrence in intermediate to high risk head and neck melanoma patients after sentinel lymph node biopsy (SLNB). This study is a retrospective review from an academic tertiary care center. Patients treated with SLNB for head and neck melanoma from 1997 to 2019 were reviewed and characterized by sentinel lymph node (SLN) status. Clinical variables were examined for the impact on regional and distant recurrence in SLNB-negative patients using univariable and multivariable Cox regression analysis. One hundred and fifty four patients were included. Of note, 127 (82.5 %) were men, and the average age was 61.3 years. Median follow-up was 68.6 weeks. Pathologic review of SLNs found 3.9% positive for metastatic melanoma; 96.1% were negative. Regional recurrence was significantly associated with tumor stage and age on multivariate analysis. A total of 4.5% of patients recurred in a previously labeled negative basin. Scalp subsite accounted for 30.5% of primary tumors and was more likely to yield a positive SLN on univariate analysis ( We report a number of prognostic trends in head and neck melanoma. SLN positivity was found more often in patients with a primary tumor of the scalp. Regional recurrence was significantly associated with age and tumor stage, whereas distant recurrence was significantly associated with tumor staging and scalp subsite. Scalp subsite was associated with an increased risk for nodal metastasis and distant recurrence. 3.
Identifiants
pubmed: 34401498
doi: 10.1002/lio2.605
pii: LIO2605
pmc: PMC8356881
doi:
Types de publication
Journal Article
Langues
eng
Pagination
738-746Subventions
Organisme : NCI NIH HHS
ID : P30 CA016042
Pays : United States
Informations de copyright
© 2021 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC. on behalf of The Triological Society.
Déclaration de conflit d'intérêts
The authors declare no potential conflict of interest.
Références
Ann Surg. 2005 Sep;242(3):302-11; discussion 311-3
pubmed: 16135917
Ann Surg. 2004 Apr;239(4):544-52
pubmed: 15024316
Br J Oral Maxillofac Surg. 2014 Apr;52(4):340-3
pubmed: 24518069
Melanoma Res. 2017 Aug;27(4):387-390
pubmed: 28234768
Ann Surg Oncol. 2017 Jan;24(1):142-149
pubmed: 27646020
CA Cancer J Clin. 2017 Nov;67(6):472-492
pubmed: 29028110
N Engl J Med. 2014 Feb 13;370(7):599-609
pubmed: 24521106
J Clin Oncol. 1993 Sep;11(9):1751-6
pubmed: 8355042
Ann Surg. 2008 Sep;248(3):378-86
pubmed: 18791358
J Surg Oncol. 2017 Sep;116(3):337-343
pubmed: 28543136
Australas J Dermatol. 2017 Aug;58(3):181-188
pubmed: 26768190
Otolaryngol Head Neck Surg. 2011 Oct;145(4):606-11
pubmed: 21659495
Oncology. 2017;93(1):18-28
pubmed: 28423377
Head Neck. 2015 Aug;37(8):1116-21
pubmed: 24764188
Ann Surg Oncol. 2014 Oct;21(11):3377-85
pubmed: 25063010
JAMA Surg. 2013 May;148(5):456-61
pubmed: 23325294
Head Neck. 2008 Oct;30(10):1284-94
pubmed: 18704971
Otolaryngol Head Neck Surg. 2011 Sep;145(3):375-82
pubmed: 21540313
Laryngoscope. 2013 Jun;123(6):1411-5
pubmed: 23625541
Arch Otolaryngol Head Neck Surg. 2006 Apr;132(4):370-3
pubmed: 16618904
Ann Surg Oncol. 2015 Nov;22(12):4073-80
pubmed: 25712801
Am J Surg. 1991 Oct;162(4):320-3
pubmed: 1951882
Am J Surg. 1970 Oct;120(4):425-31
pubmed: 5507326
Eur J Dermatol. 2011 May-Jun;21(3):354-8
pubmed: 21680279
Acta Otolaryngol. 2016;136(3):312-8
pubmed: 26767628
Head Neck. 2010 Dec;32(12):1686-92
pubmed: 20848412
J Surg Oncol. 2018 Jun;117(7):1584-1588
pubmed: 29513892
J Craniomaxillofac Surg. 2018 Jun;46(6):1027-1031
pubmed: 29735384
Arch Surg. 1992 Apr;127(4):392-9
pubmed: 1558490
Ann Surg Oncol. 2003 Jan-Feb;10(1):21-6
pubmed: 12513955
Cancer. 2012 Feb 15;118(4):1040-7
pubmed: 21773971
Otolaryngol Head Neck Surg. 2012 Oct;147(4):699-706
pubmed: 22535913
Am J Surg. 1997 Nov;174(5):536-9
pubmed: 9374232
Cutis. 2014 Nov;94(5):241-8
pubmed: 25474453
Head Neck. 2000 Jan;22(1):27-33
pubmed: 10585602
J Surg Res. 2014 Apr;187(2):518-24
pubmed: 24252855
Ann Surg Oncol. 2019 Jul;26(7):2254-2262
pubmed: 31011906
Ann Surg Oncol. 1999 Mar;6(2):150-4
pubmed: 10082039
Arch Otolaryngol Head Neck Surg. 2003 Jan;129(1):61-5
pubmed: 12525196