Optimization of betaine-sorbitol natural deep eutectic solvent-based ultrasound-assisted extraction and pancreatic lipase inhibitory activity of chlorogenic acid and caffeine content from robusta green coffee beans.

Caffeine Chlorogenic acid Natural deep eutectic solvent Pancreatic lipase Robusta green coffee beans Ultrasonic-assisted extraction

Journal

Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560

Informations de publication

Date de publication:
Aug 2021
Historique:
received: 15 05 2021
revised: 14 06 2021
accepted: 29 07 2021
entrez: 17 8 2021
pubmed: 18 8 2021
medline: 18 8 2021
Statut: epublish

Résumé

Natural deep eutectic solvent (NADES) is an alternative approach in natural product extraction with various advantages, including low toxicity, biodegradable, and suitable phytochemical compounds in a wide range of polarity. Chlorogenic acid (CGA) and caffeine, a well-known compound in the coffee bean, have various potential health benefits. This study aims to optimize the betaine-sorbitol NADES-based ultrasound-assisted extraction (UAE) method of CGA and caffeine from Robusta green coffee beans and determine the inhibitory activity of robusta green coffee beans extract of the betaine-sorbitol NADES-UAE from the optimum condition on pancreatic lipase

Identifiants

pubmed: 34401583
doi: 10.1016/j.heliyon.2021.e07702
pii: S2405-8440(21)01805-3
pmc: PMC8350192
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e07702

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Islamudin Ahmad (I)

Pharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, 75119 East Kalimantan, Indonesia.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, 75119 East Kalimantan, Indonesia.

Adisya Miftah Syakfanaya (AM)

Drug Development Laboratory, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424 West Java, Indonesia.

Azminah Azminah (A)

Faculty of Pharmacy, University of Surabaya, Surabaya, 60293 East Java, Indonesia.

Fadlina Chany Saputri (FC)

Department of Pharmacology-Toxicology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424 West Java, Indonesia.

Abdul Mun'im (A)

Drug Development Laboratory, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424 West Java, Indonesia.
Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424 West Java, Indonesia.

Classifications MeSH