The wide spectrum of COVID-19 neuropsychiatric complications within a multidisciplinary centre.

COVID-19 critical illness neuropathy encephalitis encephalopathy

Journal

Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125

Informations de publication

Date de publication:
2021
Historique:
received: 15 03 2021
revised: 29 04 2021
accepted: 05 05 2021
pubmed: 18 8 2021
medline: 18 8 2021
entrez: 17 8 2021
Statut: epublish

Résumé

A variety of neuropsychiatric complications has been described in association with COVID-19 infection. Large scale studies presenting a wider picture of these complications and their relative frequency are lacking. The objective of our study was to describe the spectrum of neurological and psychiatric complications in patients with COVID-19 seen in a multidisciplinary hospital centre over 6 months. We conducted a retrospective, observational study of all patients showing neurological or psychiatric symptoms in the context of COVID-19 seen in the medical and university neuroscience department of Assistance Publique Hopitaux de Paris-Sorbonne University. We collected demographic data, comorbidities, symptoms and severity of COVID-19 infection, neurological and psychiatric symptoms, neurological and psychiatric examination data and, when available, results from CSF analysis, MRI, EEG and EMG. A total of 249 COVID-19 patients with a

Identifiants

pubmed: 34401746
doi: 10.1093/braincomms/fcab135
pii: fcab135
pmc: PMC8344449
mid: EMS133140
doi:

Types de publication

Journal Article

Langues

eng

Pagination

fcab135

Subventions

Organisme : Medical Research Council
ID : MR/R017352/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T028750/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12023/26
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V03605X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V007181/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12023/23
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 222102
Pays : United Kingdom

Investigateurs

Cecile Delorme (C)
Jean-Christophe Corvol (JC)
Jean-Yves Delattre (JY)
Stephanie Carvalho (S)
Sandrine Sagnes (S)
Bruno Dubois (B)
Vincent Navarro (V)
Celine Louapre (C)
Tanya Stojkovic (T)
Ahmed Idbaih (A)
Charlotte Rosso (C)
David Grabli (D)
Ana Zenovia Gales (AZ)
Bruno Millet (B)
Benjamin Rohaut (B)
Eleonore Bayen (E)
Sophie Dupont (S)
Gaelle Bruneteau (G)
Stephane Lehericy (S)
Danielle Seilhean (D)
Alexandra Durr (A)
Foudil Lamari (F)
Vanessa Batista Brochard (VB)
Catherine Lubetzki (C)
Pascale Pradat-Diehl (P)
Khe Hoang-Xuan (K)
Bertrand Fontaine (B)
Lionel Naccache (L)
Philippe Fossati (P)
Isabelle Arnulf (I)
Alexandre Carpentier (A)
Yves Edel (Y)
Gilberte Robain (G)
Philippe Thoumie (P)
Bertrand Degos (B)
Tarek Sharshar (T)
Sonia Alamowitch (S)
Emmanuelle Apartis-Bourdieu (E)
Charles-Siegried Peretti (CS)
Renata Ursu (R)
Nathalie Dzierzynski (N)
Kiyoka Kinugawa Bourron (KK)
Joel Belmin (J)
Bruno Oquendo (B)
Eric Pautas (E)
Marc Verny (M)
Yves Samson (Y)
Sara Leder (S)
Anne Leger (A)
Sandrine Deltour (S)
Flore Baronnet (F)
Stephanie Bombois (S)
Mehdi Touat (M)
Marc Sanson (M)
Caroline Dehais (C)
Caroline Houillier (C)
Florence Laigle-Donadey (F)
Dimitri Psimaras (D)
Agusti Alenton (A)
Nadia Younan (N)
Nicolas Villain (N)
Maria Del Mar Amador (M)
Louise-Laure Mariani (LL)
Nicolas Mezouar (N)
Graziella Mangone (G)
Aurelie Meneret (A)
Andreas Hartmann (A)
Clement Tarrano (C)
David Bendetowicz (D)
Pierre-François Pradat (PF)
Michel Baulac (M)
Sara Sambin (S)
Phintip Pichit (P)
Florence Chochon (F)
Adele Hesters (A)
Bastien Herlin (B)
An Hung Nguyen (AH)
Valerie Porcher (V)
Alexandre Demoule (A)
Elise Morawiec (E)
Julien Mayaux (J)
Morgan Faure (M)
Claire Ewenczyk (C)
Giulia Coarelli (G)
Anna Heinzmann (A)
Marion Masingue (M)
Guillaume Bassez (G)
Isabelle An (I)
Yulia Worbe (Y)
Virginie Lambrecq (V)
Rabab Debs (R)
Esteban Munoz Musat (EM)
Timothee Lenglet (T)
Virginie Lambrecq (V)
Aurelie Hanin (A)
Lydia Chougar (L)
Nathalia Shor (N)
Nadya Pyatigorskaya (N)
Damien Galanaud (D)
Delphine Leclercq (D)
Sophie Demeret (S)
Albert Cao (A)
Clemence Marois (C)
Nicolas Weiss (N)
Salimata Gassama (S)
Loic Le Guennec (L)
Vincent Degos (V)
Alice Jacquens (A)
Thomas Similowski (T)
Capucine Morelot-Panzini (C)
Jean-Yves Rotge (JY)
Bertrand Saudreau (B)
Victor Pitron (V)
Nassim Sarni (N)
Nathalie Girault (N)
Redwan Maatoug (R)
Smaranda Leu (S)
Lionel Thivard (L)
Karima Mokhtari (K)
Isabelle Plu (I)
Bruno Gonçalves (B)
Laure Bottin (L)
Marion Yger (M)
Gaelle Ouvrard (G)
Rebecca Haddad (R)
Flora Ketz (F)
Carmelo Lafuente (C)
Christel Oasi (C)
Bruno Megabarne (B)
Dominique Herve (D)
Haysam Salman (H)
Armelle Rametti-Lacroux (A)
Alize Chalançon (A)
Anais Herve (A)
Hugo Royer (H)
Florence Beauzor (F)
Valentine Maheo (V)
Christelle Laganot (C)
Camille Minelli (C)
Aurelie Fekete (A)
Abel Grine (A)
Marie Biet (M)
Rania Hilab (R)
Aurore Besnard (A)
Meriem Bouguerra (M)
Gwen Goudard (G)
Saida Houairi (S)
Saba Al-Youssef (S)
Christine Pires (C)
Anissa Oukhedouma (A)
Katarzyna Siuda-Krzywicka (K)
Tal Seidel Malkinson (TS)
Hanane Agguini (H)
Safia Said (S)
Marion Houot (M)

Informations de copyright

© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

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Auteurs

Cécile Delorme (C)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Marion Houot (M)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Charlotte Rosso (C)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Stéphanie Carvalho (S)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Thomas Nedelec (T)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Redwan Maatoug (R)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Victor Pitron (V)

Service de Psychiatrie adulte, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France.

Salimata Gassama (S)

Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France.

Sara Sambin (S)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Stéphanie Bombois (S)

Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Institut de la Mémoire et de la maladie d'Alzheimer, Paris 75013, France.

Bastien Herlin (B)

Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Unité d'épileptologie, Paris 75013, France.

Gaëlle Ouvrard (G)

Service de Neuro-orthopédie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Rothschild Hospital, Paris 75012, France.

Gaëlle Bruneteau (G)

Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France.

Adèle Hesters (A)

Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France.

Ana Zenovia Gales (AZ)

Service des Pathologies du sommeil, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France.

Bruno Millet (B)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Foudil Lamari (F)

Département de Biochimie Métabolique, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France.

Stéphane Lehericy (S)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Vincent Navarro (V)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Benjamin Rohaut (B)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Sophie Demeret (S)

Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France.

Thierry Maisonobe (T)

Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France.

Marion Yger (M)

Unité de Soins intentifs neurovasculaires, Assistance Publique Hôpitaux de Paris, Sorbonne Université Saint-Antoine Hospital, Paris 75012, France.

Bertrand Degos (B)

Département de Neurologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Avicenne Hospital, Bobigny 93000, France.

Louise-Laure Mariani (LL)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Christophe Bouche (C)

Service de Psychiatrie adulte, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris 75013, France.

Nathalie Dzierzynski (N)

Département de Psychiatrie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Tenon Hospital, Paris 75020, France.

Bruno Oquendo (B)

Service de Gériatrie à orientation neurologique, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière Charles Foix Hospital, Paris 94200, France.

Flora Ketz (F)

Service de Gériatrie polyvalente, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Charles Foix Hospital, Paris 94200, France.

An-Hung Nguyen (AH)

Service d'Addictologie, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié-Salpêtrière, Paris 75013, France.

Aurélie Kas (A)

Service de Médecine Nucléaire et LIB, INSERM U1146, Assistance Publique Hôpitaux de Paris, Sorbonne Université, Pitié- Salpêtrière Hospital, Paris 75013, France.

Catherine Lubetzki (C)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Jean-Yves Delattre (JY)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Jean-Christophe Corvol (JC)

CNRS UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, Inserm U1127, Paris 75013, France.

Classifications MeSH