Genetic Obesity Variants and Risk of Conventional Adenomas and Serrated Polyps.

Adenoma / genetics Body Mass Index Colonic Polyps / genetics Colonoscopy Colorectal Neoplasms / epidemiology Female Follow-Up Studies Humans Obesity / epidemiology Polymorphism, Single Nucleotide
Body mass index (BMI) Colorectal cancer Conventional adenoma Mendelian randomization Serrated polyp

Journal

Digestive diseases and sciences
ISSN: 1573-2568
Titre abrégé: Dig Dis Sci
Pays: United States
ID NLM: 7902782

Informations de publication

Date de publication:
08 2022
Historique:
received: 29 05 2021
accepted: 20 07 2021
pubmed: 18 8 2021
medline: 20 7 2022
entrez: 17 8 2021
Statut: ppublish

Résumé

Higher body mass index (BMI) is associated with increased risk of colorectal cancer. How genetically predicted BMI may be associated with colorectal cancer precursors is unknown. Our objective was to quantify the association of genetically predicted and measured BMI with risk of colorectal cancer precursors. We evaluated the association of genetically predicted and measured BMI with risk of conventional adenomas, serrated polyps, and synchronous polyps among 27,426 participants who had undergone at least one lower gastrointestinal endoscopy in the Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-up Study. Genetic risk score was derived from 97 BMI-related single nucleotide polymorphisms. Multivariable logistic regression evaluated each polyp subtype compared to non-polyps. For conventional adenomas, the OR per 2-kg/m Genetically predicted BMI was not associated with colorectal cancer precursor lesions. The confidence intervals were wide and encompassed those for measured BMI, indicating that null findings may be due to insufficient power.

Sections du résumé

BACKGROUND
Higher body mass index (BMI) is associated with increased risk of colorectal cancer. How genetically predicted BMI may be associated with colorectal cancer precursors is unknown.
AIMS
Our objective was to quantify the association of genetically predicted and measured BMI with risk of colorectal cancer precursors.
METHODS
We evaluated the association of genetically predicted and measured BMI with risk of conventional adenomas, serrated polyps, and synchronous polyps among 27,426 participants who had undergone at least one lower gastrointestinal endoscopy in the Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-up Study. Genetic risk score was derived from 97 BMI-related single nucleotide polymorphisms. Multivariable logistic regression evaluated each polyp subtype compared to non-polyps.
RESULTS
For conventional adenomas, the OR per 2-kg/m
CONCLUSION
Genetically predicted BMI was not associated with colorectal cancer precursor lesions. The confidence intervals were wide and encompassed those for measured BMI, indicating that null findings may be due to insufficient power.

Identifiants

DOI: 10.1007/s10620-021-07193-x PMID: 34403030 PMC: PMC9255950
pubmed: 34403030
doi: 10.1007/s10620-021-07193-x
pii: 10.1007/s10620-021-07193-x
pmc: PMC9255950
mid: NIHMS1815901
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4078-4085

Subventions

Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA067262
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202704
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA167552
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007753
Pays : United States
Organisme : NIDDK NIH HHS
ID : K24 DK098311
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA055075
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA176726
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA137178
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA176272
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM144273
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA215314
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA215314
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA049449
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA253185
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Références

Gut. 2006 Feb;55(2):285-91
pubmed: 16239255
Diabetes. 2018 Feb;67(2):248-255
pubmed: 29212779
PLoS One. 2015 Mar 17;10(3):e0121971
pubmed: 25781614
Cancer Epidemiol Biomarkers Prev. 2015 Jul;24(7):1024-31
pubmed: 25976416
Carcinogenesis. 2011 May;32(5):748-56
pubmed: 21317302
Br J Cancer. 2016 Jul 12;115(2):266-72
pubmed: 27336604
Gastroenterology. 2020 Mar;158(4):852-861.e4
pubmed: 31302144
United European Gastroenterol J. 2018 Dec;6(10):1538-1546
pubmed: 30574324
Cancer Epidemiol Biomarkers Prev. 2013 Dec;22(12):2303-11
pubmed: 24127414
Cancer Epidemiol Biomarkers Prev. 2015 Apr;24(4):690-7
pubmed: 25777804
Cancer Causes Control. 2013 Jun;24(6):1207-22
pubmed: 23563998
Gastroenterology. 2012 Apr;142(4):762-72
pubmed: 22245665
Carcinogenesis. 2009 Jul;30(7):1073-81
pubmed: 19468060
Nat Genet. 2007 Jul;39(7):870-4
pubmed: 17529973
Nat Genet. 2006 Aug;38(8):904-9
pubmed: 16862161
Gastroenterology. 2017 Jan;152(1):92-104
pubmed: 27639804
Int J Epidemiol. 2016 Jun;45(3):896-908
pubmed: 27427428
Rev Panam Salud Publica. 2019 Jan 04;43:e3
pubmed: 31093227
Sci Rep. 2017 Feb 15;7:42573
pubmed: 28198450
Nature. 2015 Feb 12;518(7538):197-206
pubmed: 25673413
Gastroenterology. 2018 Aug;155(2):355-373.e18
pubmed: 29702117

Auteurs

Alaina M Bever (AM)

Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
Harvard Medical School, Boston, MA, USA.

Dong Hang (D)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Nanjing Medical University, Nanjing, China.

Xiaosheng He (X)

Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Amit D Joshi (AD)

Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.

Ming Ding (M)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Kana Wu (K)

Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA.
Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.

Andrew T Chan (AT)

Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.

Edward L Giovannucci (EL)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Mingyang Song (M)

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. msong@hsph.harvard.edu.
Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. msong@hsph.harvard.edu.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. msong@hsph.harvard.edu.
ORCID: 0000-0002-1324-0316

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Adénomes › Genetic Obesity Variants and Risk of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Genetic Obesity Variants and Risk of...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Polypes › Polypes intestinaux › Polypes coliques › Genetic Obesity Variants and Risk of...
questionsmedicales.fr › Procédures de chirurgie opératoire › Interventions chirurgicales mini-invasives › Endoscopie › Endoscopie digestive › Endoscopie gastrointestinale › Coloscopie › Genetic Obesity Variants and Risk of...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Genetic Obesity Variants and Risk of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Genetic Obesity Variants and Risk of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic Obesity Variants and Risk of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Genetic Obesity Variants and Risk of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genetic Obesity Variants and Risk of...