Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients.
Aged
Arthroplasty, Replacement, Hip
/ methods
Arthroplasty, Replacement, Knee
/ methods
Biomarkers
/ urine
Cohort Studies
Female
Hip Joint
/ surgery
Humans
Inflammation
/ metabolism
Knee Joint
/ surgery
Male
Middle Aged
Neopterin
/ analysis
Osteoarthritis, Hip
/ surgery
Osteoarthritis, Knee
/ surgery
Oxidative Stress
/ physiology
Stress, Physiological
/ physiology
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
04
2021
accepted:
29
07
2021
entrez:
17
8
2021
pubmed:
18
8
2021
medline:
16
12
2021
Statut:
epublish
Résumé
Knee and hip arthroplasty are common surgeries within an aging population. Some data has suggested that knee arthroplasty is more traumatic to the body than hip arthroplasty due to the increased complexity and load bearing nature of the joint. Here, we compare the stress of the two surgeries by measuring urinary neopterin and total neopterin as biomarkers of oxidative stress and inflammation. Urinary neopterin and total neopterin (neopterin + 7,8-dihydroneopterin) levels were analysed in 28 knee and 22 hip arthroplasty patients pre- and post-operatively to determine oxidative stress and inflammation levels. Total neopterin was 31.1% higher with knee arthroplasty (p<0.05). Urinary neopterin was 32.8% higher in the knee arthroplasty group versus hips. The increase in neopterin and total neopterin following a post-surgical decrease in levels was significant in both groups. Levels of neopterin and total neopterin were varied between patients, but all increased following surgery and subsided by day 28. The increased levels of urinary neopterin and total neopterin from knee arthroplasty indicate that knee osteoarthritis and arthroplasty is a more significant trauma to the body than hip osteoarthritis and arthroplasty surgery. This is also shown by faster inflammatory resolution following hip arthroplasty.
Identifiants
pubmed: 34403444
doi: 10.1371/journal.pone.0256072
pii: PONE-D-21-13903
pmc: PMC8370602
doi:
Substances chimiques
Biomarkers
0
Neopterin
670-65-5
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0256072Déclaration de conflit d'intérêts
We can confirm that none of the authors has any competing or commercial connection to the research described.
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