Disorders of Fibrinogen and Fibrinolysis.

Blood Coagulation Fibrin Fibrinogen Fibrinolysis Hemostatics Humans Thrombosis
Afibrinogenemia Coagulation D-dimer Dysfibrinogenemia Fibrinogen Fibrinolysis Hemostasis Hypofibrinogenemia

Journal

Hematology/oncology clinics of North America
ISSN: 1558-1977
Titre abrégé: Hematol Oncol Clin North Am
Pays: United States
ID NLM: 8709473

Informations de publication

Date de publication:
12 2021
Historique:
pubmed: 19 8 2021
medline: 3 3 2022
entrez: 18 8 2021
Statut: ppublish

Résumé

Fibrinogen plays a fundamental role in coagulation through its support for platelet aggregation and its conversion to fibrin. Fibrin stabilizes clots and serves as a scaffold and immune effector before being broken down by the fibrinolytic system. Given its importance, abnormalities in fibrin(ogen) and fibrinolysis result in a variety of disorders with hemorrhagic and thrombotic manifestations. This review summarizes (i) the basic elements of fibrin(ogen) and its role in coagulation and the fibrinolytic system; (ii) the laboratory evaluation for fibrin(ogen) disorders, including the use of global fibrinolysis assays; and (iii) the management of congenital and acquired disorders of fibrinogen and fibrinolysis.

Identifiants

DOI: 10.1016/j.hoc.2021.07.011 PMID: 34404562 PMC: PMC10125022
pubmed: 34404562
pii: S0889-8588(21)00090-3
doi: 10.1016/j.hoc.2021.07.011
pmc: PMC10125022
mid: NIHMS1888499
pii:
doi:

Substances chimiques

Hemostatics 0
Fibrin 9001-31-4
Fibrinogen 9001-32-5

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1197-1217

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL126974
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141291
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure A.S. Wolberg has received research funding from Bristol Myers Squibb, Takeda, and Stago. M.Y. Lim reports receiving honoraria from American Society of Hematology, and consulting fee from Sanofi Genzyme and Argenx. J.E. May declares no conflict of interests.

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Auteurs

Jori E May (JE)

Division of Hematology/Oncology, University of Alabama at Birmingham, 1720 2nd Avenue South, NP 2503, Birmingham, AL 35294, USA.

Alisa S Wolberg (AS)

UNC Department of Pathology and Laboratory Medicine, UNC Blood Research Center, 8018A Mary Ellen Jones Building, CB7035, Chapel Hill, NC 27599-7035, USA.

Ming Yeong Lim (MY)

Department of Internal Medicine, Division of Hematology and Hematologic Malignancies, University of Utah, 2000 Circle Hope Drive, Room 4126, Salt Lake City, UT 84112, USA. Electronic address: ming.lim@hsc.utah.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Coagulation sanguine › Disorders of Fibrinogen and Fibrinolysis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Fibrine › Disorders of Fibrinogen and Fibrinolysis.
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Fibrinogène › Disorders of Fibrinogen and Fibrinolysis.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Coagulation sanguine › Fibrinolyse › Disorders of Fibrinogen and Fibrinolysis.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Coagulants › Hémostatiques › Disorders of Fibrinogen and Fibrinolysis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Disorders of Fibrinogen and Fibrinolysis.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › Disorders of Fibrinogen and Fibrinolysis.