Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern.
Angiotensin-Converting Enzyme 2
/ immunology
Animals
Antibodies, Monoclonal
/ blood
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ blood
COVID-19
/ immunology
COVID-19 Vaccines
/ administration & dosage
Carrier Proteins
Epitopes
Humans
Immunity
SARS-CoV-2
/ drug effects
T-Lymphocytes
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 08 2021
17 08 2021
Historique:
received:
25
03
2021
accepted:
19
07
2021
entrez:
18
8
2021
pubmed:
19
8
2021
medline:
26
8
2021
Statut:
epublish
Résumé
The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune responses to protect against these and other emergent variants.
Identifiants
pubmed: 34404775
doi: 10.1038/s41467-021-25167-5
pii: 10.1038/s41467-021-25167-5
pmc: PMC8371089
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Carrier Proteins
0
Epitopes
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Banques de données
ISRCTN
['ISRCTN10980107']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5061Subventions
Organisme : Medical Research Council
ID : MR/V028448/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L006588/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V027859/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/18/3/34214
Pays : United Kingdom
Organisme : Department of Health
ID : NIHR200907
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211153/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Department of Health
ID : NIHR300791
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 109965/Z/15/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_20060
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 216417/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT109965MA
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204721/Z/16/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Investigateurs
Senthil Chinnakannan
(S)
Timothy Donnison
(T)
Mohammad Ali
(M)
Patpong Rongkard
(P)
Matthew Pace
(M)
Peny Zacharopoulou
(P)
Nicola Robinson
(N)
Anna Csala
(A)
Cathy De Lara
(C)
Claire L Hutchings
(CL)
Hema Mehta
(H)
Lian Ni Lee
(LN)
Matthew Edmans
(M)
Carl-Philipp Hackstein
(CP)
Prabhjeet Phalora
(P)
Wenqin Li
(W)
Eloise Phillips
(E)
Tom Malone
(T)
Ane Ogbe
(A)
Cecilia Jay
(C)
Timothy Tipoe
(T)
Thomas Marjot
(T)
Stavros Dimitriadis
(S)
Beatrice Simmons
(B)
Alexandra Deeks
(A)
Sven Kerneis
(S)
Hibatullah Abuelgasim
(H)
Robert Wilson
(R)
Sarah R Thomas
(SR)
Adam Watson
(A)
Ahmed Alhussni
(A)
Joseph Cutteridge
(J)
Esme Weeks
(E)
Lucy Denly
(L)
Katy Lillie
(K)
Jennifer Holmes
(J)
Philppa C Matthews
(PC)
Denise O'Donnell
(D)
Lance Turtle
(L)
Thushan de Silva
(T)
Alex Richter
(A)
Christopher J A Duncan
(CJA)
Rebecca P Payne
(RP)
Shona C Moore
(SC)
Julian C Knight
(JC)
Mark Philip Cassar
(MP)
Betty Raman
(B)
Stefan Neubauer
(S)
Anastasia Fries
(A)
Nick P Talbot
(NP)
Nayia Petousi
(N)
Ling-Pei Ho
(LP)
Yanchun Peng
(Y)
Tao Dong
(T)
Susana Camara
(S)
Spyridoula Marinou
(S)
Aline Linder
(A)
Syed Adlou
(S)
Mwila Kasanyinga
(M)
Alice Bridges-Webb
(A)
Jennifer Hill
(J)
Laura Silva-Reyes
(L)
Luke Blackwell
(L)
Informations de copyright
© 2021. The Author(s).
Références
Med J Aust. 2020 Jun;212(10):459-462
pubmed: 32237278
Nat Med. 2021 Apr;27(4):622-625
pubmed: 33654292
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Cell Rep Med. 2021 Jul 20;2(7):100355
pubmed: 34230917
Science. 2021 Mar 12;371(6534):1152-1153
pubmed: 33514629
PLoS Med. 2006 Jul;3(7):e237
pubmed: 16796401
Nat Med. 2013 Oct;19(10):1305-12
pubmed: 24056771
Cell. 2020 Sep 3;182(5):1295-1310.e20
pubmed: 32841599
BMJ. 2021 Jan 14;372:n124
pubmed: 33446481
Nat Microbiol. 2019 Feb;4(2):306-315
pubmed: 30478290
Science. 2020 Aug 14;369(6505):806-811
pubmed: 32434945
PLoS Pathog. 2021 Feb 26;17(2):e1009352
pubmed: 33635919
Nature. 2021 May;593(7857):136-141
pubmed: 33706364
Lancet Respir Med. 2021 Apr;9(4):333-335
pubmed: 33524316
Nature. 2020 Aug;584(7821):437-442
pubmed: 32555388
J Biomol Struct Dyn. 2022;40(20):9724-9741
pubmed: 34060425
Science. 2021 Jan 29;371(6528):521-526
pubmed: 33510029
Nature. 2021 May;593(7857):142-146
pubmed: 33780970
Lancet. 2020 Aug 15;396(10249):467-478
pubmed: 32702298
Nature. 2020 Jul;583(7815):290-295
pubmed: 32422645
Nat Med. 2012 Jan 29;18(2):274-80
pubmed: 22286307
Nature. 2021 Apr;592(7854):438-443
pubmed: 33690265
Trends Mol Med. 2016 Nov;22(11):969-982
pubmed: 27756530
BMJ. 2021 Feb 1;372:n296
pubmed: 33526412
N Engl J Med. 2021 Feb 11;384(6):533-540
pubmed: 33369366
Nat Med. 2021 Feb;27(2):279-288
pubmed: 33335322
Nat Rev Immunol. 2021 Feb;21(2):73-82
pubmed: 33340022
Nat Commun. 2021 Apr 6;12(1):2055
pubmed: 33824342
N Engl J Med. 2021 Mar 8;384(15):1466-1468
pubmed: 33684280
Nature. 2021 Feb;590(7847):630-634
pubmed: 33276369
Lancet. 2021 Feb 20;397(10275):671-681
pubmed: 33545094
Vaccine. 2021 Aug 9;39(34):4885-4894
pubmed: 34253420
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
Nature. 2021 Apr;592(7855):616-622
pubmed: 33567448
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Nature. 2020 Oct;586(7830):583-588
pubmed: 32731257
Cell. 2021 Aug 5;184(16):4220-4236.e13
pubmed: 34242578
Sci Rep. 2019 Feb 22;9(1):2617
pubmed: 30796267
Nat Commun. 2021 Feb 15;12(1):1018
pubmed: 33589636
Nat Immunol. 2020 Nov;21(11):1336-1345
pubmed: 32887977
Cell. 2020 Aug 20;182(4):828-842.e16
pubmed: 32645326
N Engl J Med. 2021 May 20;384(20):1885-1898
pubmed: 33725432
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Vaccines (Basel). 2021 Mar 10;9(3):
pubmed: 33801831