Orexin contributes to eupnea within a critical period of postnatal development.
Animals
Animals, Newborn
Azepines
/ pharmacology
Chemoreceptor Cells
/ drug effects
Hypercapnia
/ metabolism
Hypoxia
/ metabolism
Lung
/ innervation
Orexin Receptor Antagonists
/ pharmacology
Orexin Receptors
/ metabolism
Orexins
/ metabolism
Pulmonary Ventilation
/ drug effects
Rats, Sprague-Dawley
Reflex
/ drug effects
Respiratory Mechanics
/ drug effects
Sleep
Triazoles
/ pharmacology
Wakefulness
breathing
chemoreflex
eupnea
infant
orexin
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
pubmed:
19
8
2021
medline:
21
10
2021
entrez:
18
8
2021
Statut:
ppublish
Résumé
Orexin neurons are active in wakefulness and mostly silent in sleep. In adult rats and humans, orexin facilitates the hypercapnic ventilatory response but has little effect on resting ventilation. The influence of orexin on breathing in the early postnatal period, and across states of vigilance, have not been investigated. This is relevant as the orexin system may be impaired in Sudden Infant Death Syndrome (SIDS) cases. We addressed three hypotheses:
Identifiants
pubmed: 34405704
doi: 10.1152/ajpregu.00156.2021
pmc: PMC8560369
doi:
Substances chimiques
Azepines
0
Orexin Receptor Antagonists
0
Orexin Receptors
0
Orexins
0
Triazoles
0
suvorexant
081L192FO9
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
R558-R571Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL136710
Pays : United States
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : 5R01HL136710
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