The sheep as a pre-clinical model for testing intra-aortic percutaneous mechanical circulatory support devices.
3R
Mechanical circulatory support
animal model
preclinical study
sheep
thoracic aorta
Journal
The International journal of artificial organs
ISSN: 1724-6040
Titre abrégé: Int J Artif Organs
Pays: United States
ID NLM: 7802649
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
pubmed:
19
8
2021
medline:
22
9
2021
entrez:
18
8
2021
Statut:
ppublish
Résumé
The save deployment of intra-aortic percutaneous mechanical circulatory support devices is highly dependent on the inner aortic diameter. Finding the anatomically and ethically most suitable animal model for performance testing of new pMCS devices remains challenging. For this study, an ovine model using adult ewes of a large framed breed (Swiss White Alpine Sheep) was developed to test safety, reliability, and biocompatibility of catheter-mounted mechanical support devices placed in the descending thoracic aorta. Following the drawback of fluctuating aortic diameter and device malfunction in the first four animals, the model was improved by stenting the following animals with an aortic stent. Stenting the animals with an intra-aortic over the balloon stent was found to standardize the experimental set-up and to avoid early termination of the experiment due to non-device related issues.
Identifiants
pubmed: 34405723
doi: 10.1177/03913988211025537
pmc: PMC8450982
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
703-710Références
Heart. 2006 Jan;92(1):137-42
pubmed: 16365370
Sci Technol Human Values. 2018 Jul;43(4):622-648
pubmed: 30008492
Front Cardiovasc Med. 2019 Jun 07;6:72
pubmed: 31231661
Int J Cardiol. 2013 Feb 10;163(1):72-8
pubmed: 21641667
Circ Res. 1979 Mar;44(3):420-9
pubmed: 104801
Circulation. 1995 Oct 15;92(8):2210-9
pubmed: 7554204
Circ Heart Fail. 2018 Aug;11(8):e005115
pubmed: 30354560
Clin Imaging. 2016 Sep-Oct;40(5):936-43
pubmed: 27203287
ASAIO J. 2014 Jan-Feb;60(1):2-8
pubmed: 24270232
J Card Fail. 2007 Aug;13(6):422-30
pubmed: 17675055
Schweiz Arch Tierheilkd. 2014 Oct;156(10):489-97
pubmed: 25273870
J Cardiothorac Surg. 2011 Aug 09;6:95
pubmed: 21827666
JACC Cardiovasc Interv. 2017 Apr 24;10(8):841
pubmed: 28427603
ASAIO J. 1999 Jul-Aug;45(4):317-21
pubmed: 10445738
Transl Med UniSa. 2016 Jan 31;13:4-12
pubmed: 27042427
Integr Blood Press Control. 2013 Apr 30;6:27-38
pubmed: 23667317
Rev Esp Cardiol (Engl Ed). 2017 May;70(5):382-390
pubmed: 28153551
JACC Cardiovasc Interv. 2016 Nov 28;9(22):2292-2303
pubmed: 28026740
J Am Assoc Lab Anim Sci. 2014 Sep;53(5):432-8
pubmed: 25255064
Int J Cardiol. 2015 Dec 15;201:684-91
pubmed: 26363632
Cardiol Clin. 2011 Nov;29(4):559-82
pubmed: 22062206
Sci Rep. 2020 Jul 24;10(1):12417
pubmed: 32709984
Med Eng Phys. 2011 Apr;33(3):263-80
pubmed: 21075669
J Vasc Surg. 2018 Jan;67(1):300-308.e2
pubmed: 28479097
Int J Cardiol. 2015 Jan 15;178:153-8
pubmed: 25464241
ASAIO J. 2003 Jul-Aug;49(4):355-64
pubmed: 12918574
Heart Fail Clin. 2013 Jul;9(3):359-67, vii
pubmed: 23809421
J Thorac Cardiovasc Surg. 2017 Jul;154(1):291-300
pubmed: 28495065
Cardiol Ther. 2019 Dec;8(2):211-228
pubmed: 31646440
Biomaterials. 1980 Apr;1(2):103-7
pubmed: 7470555
J Pharmacol Exp Ther. 1997 Sep;282(3):1219-27
pubmed: 9316829
Clin Phys Physiol Meas. 1982 Aug;3(3):201-12
pubmed: 7140158
Circ Heart Fail. 2009 May;2(3):262-71
pubmed: 19808348
Crit Care Med. 2017 Nov;45(11):1922-1929
pubmed: 28857849