Resolvin D1 protects against cadmium chloride-induced memory loss and hippocampal damage in rats: A comparison with docosahexaenoic acid.

Animals Cadmium Chloride / toxicity Docosahexaenoic Acids / pharmacology Hippocampus / drug effects Male Maze Learning Memory Disorders / chemically induced Neuroprotective Agents / pharmacology Rats Rats, Wistar
Cadmium Docosahexaenoic acid NF-kB Nrf2 hippocampus memory resolvin D1

Journal

Human & experimental toxicology
ISSN: 1477-0903
Titre abrégé: Hum Exp Toxicol
Pays: England
ID NLM: 9004560

Informations de publication

Date de publication:
Dec 2021
Historique:
pubmed: 19 8 2021
medline: 15 3 2022
entrez: 18 8 2021
Statut: ppublish

Résumé

Intoxication with cadmium (Cd) ions leads to hippocampal damage and cognitive impairment. However, omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert neuroprotective effects in different animal models of neurodegeneration. This study compared the neuroprotective effect of the n-3 PUFA, docosahexaenoic acid (DHA), and its downstream metabolite, resolvin D1 (RVD1), on hippocampal damage and memory deficits in cadmium chloride (CdCl Control or CdCl Treatment with a DHA-rich diet or RVD1 significantly increased the levels of docosahexaenoic acid and RVD1, respectively, in the hippocampal of CdCl RVD1 is more powerful than DHA in preventing CdCl

Sections du résumé

BACKGROUND BACKGROUND
Intoxication with cadmium (Cd) ions leads to hippocampal damage and cognitive impairment. However, omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert neuroprotective effects in different animal models of neurodegeneration.
PURPOSE OBJECTIVE
This study compared the neuroprotective effect of the n-3 PUFA, docosahexaenoic acid (DHA), and its downstream metabolite, resolvin D1 (RVD1), on hippocampal damage and memory deficits in cadmium chloride (CdCl
RESEARCH DESIGN METHODS
Control or CdCl
RESULTS RESULTS
Treatment with a DHA-rich diet or RVD1 significantly increased the levels of docosahexaenoic acid and RVD1, respectively, in the hippocampal of CdCl
CONCLUSION CONCLUSIONS
RVD1 is more powerful than DHA in preventing CdCl

Identifiants

DOI: 10.1177/09603271211038739 PMID: 34405727
pubmed: 34405727
doi: 10.1177/09603271211038739
doi:

Substances chimiques

Neuroprotective Agents 0
resolvin D1 0
Docosahexaenoic Acids 25167-62-8
Cadmium Chloride J6K4F9V3BA

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

S215-S232

Auteurs

Ali A Shati (AA)

Department of Biology, College of Science, 48144King Khalid University, Abha, Saudi Arabia.
ORCID: 0000-0003-1800-7238

Attalla F El-Kott (AF)

Department of Biology, College of Science, 48144King Khalid University, Abha, Saudi Arabia.
Department of Zoology, Faculty of Science, Damanhour University, Damanhour, Egypt.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Resolvin D1 protects against cadmium...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du chlore › Acide chlorhydrique › Chlorure de cadmium › Resolvin D1 protects against cadmium...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Acide docosahexaénoïque › Resolvin D1 protects against cadmium...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Resolvin D1 protects against cadmium...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Apprentissage du labyrinthe › Resolvin D1 protects against cadmium...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles de la mémoire › Resolvin D1 protects against cadmium...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Resolvin D1 protects against cadmium...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Resolvin D1 protects against cadmium...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Resolvin D1 protects against cadmium...