Autophagy impairment by African swine fever virus.
African swine fever
DNA virus
host-pathogen interactions
immune evasion
transcription
Journal
The Journal of general virology
ISSN: 1465-2099
Titre abrégé: J Gen Virol
Pays: England
ID NLM: 0077340
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
entrez:
18
8
2021
pubmed:
19
8
2021
medline:
7
9
2021
Statut:
ppublish
Résumé
African swine fever is a devastating disease of domestic swine and wild boar caused by a large double-stranded DNA virus that encodes for more than 150 open reading frames. There is no licensed vaccine for the disease and the most promising current candidates are modified live viruses that have been attenuated by deletion of virulence factors. Like many viruses African swine fever virus significantly alters the host cell machinery to benefit its replication and viral genes that modify host pathways represent promising targets for development of gene deleted vaccines. Autophagy is an important cellular pathway that is involved in cellular homeostasis, innate and adaptive immunity and therefore is manipulated by a number of different viruses. Autophagy is regulated by a complex protein cascade and here we show that African swine fever virus can block formation of autophagosomes, a critical functional step of the autophagy pathway through at least two different mechanisms. Interestingly this does not require the
Identifiants
pubmed: 34406116
doi: 10.1099/jgv.0.001637
pmc: PMC8513644
doi:
Substances chimiques
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/F/000PR10353
Pays : United Kingdom
Références
J Virol. 2017 Nov 30;91(24):
pubmed: 28978700
J Virol. 2015 Jun;89(11):6048-56
pubmed: 25810553
J Biol Chem. 1998 Feb 13;273(7):3963-6
pubmed: 9461583
PLoS Pathog. 2009 Aug;5(8):e1000562
pubmed: 19714237
Cell. 2005 Jan 28;120(2):159-62
pubmed: 15680321
Trends Cell Biol. 2010 Jun;20(6):355-62
pubmed: 20356743
EMBO J. 1996 Dec 2;15(23):6541-51
pubmed: 8978681
Autophagy. 2011 Dec;7(12):1434-47
pubmed: 22024753
Viruses. 2019 Feb 01;11(2):
pubmed: 30717138
Annu Rev Genet. 2009;43:67-93
pubmed: 19653858
PLoS Biol. 2005 May;3(5):e156
pubmed: 15884975
J Virol. 1998 Nov;72(11):8586-96
pubmed: 9765397
Genes Dev. 2010 Dec 1;24(23):2627-39
pubmed: 21123650
J Virol. 2000 Feb;74(3):1275-85
pubmed: 10627538
Curr Mol Med. 2013 Feb;13(2):305-16
pubmed: 23228131
Curr Opin Cell Biol. 2010 Apr;22(2):124-31
pubmed: 20034776
Sci Rep. 2020 Jan 16;10(1):494
pubmed: 31949276
J Virol. 2009 Jul;83(13):6883-99
pubmed: 19386722
J Virol. 2002 Apr;76(7):3095-104
pubmed: 11884534
J Biol Chem. 2000 Jan 14;275(2):992-8
pubmed: 10625637
J Virol. 2018 Nov 12;92(23):
pubmed: 30185597
Sci Rep. 2017 Aug 9;7(1):7642
pubmed: 28794469
J Virol. 1998 Apr;72(4):2881-9
pubmed: 9525608
J Virol. 2013 Jan;87(2):859-71
pubmed: 23115300
Prog Mol Biol Transl Sci. 2012;106:223-50
pubmed: 22340720
Vaccine. 2016 Sep 7;34(39):4698-4705
pubmed: 27521231
Curr Top Microbiol Immunol. 2009;335:323-33
pubmed: 19802573
J Virol. 2013 Mar;87(5):2508-17
pubmed: 23255786
Arch Virol. 2011 Apr;156(4):597-609
pubmed: 21203785
J Virol. 2017 Oct 13;91(21):
pubmed: 28814514
J Biol Chem. 2005 Jun 24;280(25):23433-6
pubmed: 15878852
J Virol. 2002 Apr;76(8):3731-8
pubmed: 11907212
J Virol. 2020 Apr 16;94(9):
pubmed: 32075923
J Virol. 2012 Jun;86(12):6677-87
pubmed: 22496232
J Biol Chem. 2005 Sep 16;280(37):32081-9
pubmed: 16027121
J Virol. 2011 Sep;85(18):9369-76
pubmed: 21734039
Autophagy. 2006 Jan-Mar;2(1):24-9
pubmed: 16874088
Aging (Albany NY). 2017 Dec 12;9(12):2461-2462
pubmed: 29232655
Immunity. 2007 Jan;26(1):79-92
pubmed: 17182262
Virology. 2016 Jun;493:154-61
pubmed: 27043071
Cold Spring Harb Perspect Biol. 2012 Sep 01;4(9):a011189
pubmed: 22952397
Virus Res. 2019 Jun;266:25-33
pubmed: 30959069
Cell Host Microbe. 2007 Mar 15;1(1):23-35
pubmed: 18005679
Viruses. 2019 Aug 27;11(9):
pubmed: 31461953
Sci China Life Sci. 2020 May;63(5):623-634
pubmed: 32124180
J Biol Chem. 2008 Nov 28;283(48):33175-82
pubmed: 18772134
J Virol. 2015 Aug;89(16):8556-66
pubmed: 26063424
Virus Res. 2013 Apr;173(1):87-100
pubmed: 23165138
Virology. 2006 Jun 5;349(2):254-63
pubmed: 16643977
Vaccine. 2011 Jun 20;29(28):4593-600
pubmed: 21549789
Nat Med. 1997 Jun;3(6):614-20
pubmed: 9176486
J Virol. 2004 Feb;78(4):1858-64
pubmed: 14747550
J Biol Chem. 2004 Mar 12;279(11):10136-41
pubmed: 14699140
J Gen Virol. 2005 Sep;86(Pt 9):2445-2450
pubmed: 16099902
Annu Rev Biochem. 1999;68:965-1014
pubmed: 10872470
Nat Cell Biol. 2013 Jul;15(7):713-20
pubmed: 23817233
J Virol. 2009 Dec;83(23):12164-71
pubmed: 19759141
Science. 2012 Nov 16;338(6109):956-9
pubmed: 23112296
Virology. 1997 Feb 17;228(2):400-4
pubmed: 9123849
Science. 2005 Feb 18;307(5712):1098-101
pubmed: 15718470
J Virol. 1993 Jul;67(7):4391-4
pubmed: 8389936
Cell Struct Funct. 1998 Feb;23(1):33-42
pubmed: 9639028
Nat Immunol. 2009 May;10(5):480-7
pubmed: 19305394
J Virol. 2005 Jul;79(13):8388-99
pubmed: 15956583
Virus Res. 2016 Aug 2;221:8-14
pubmed: 27182007
J Virol. 1996 Dec;70(12):8865-71
pubmed: 8971015
J Virol. 2017 Feb 28;91(6):
pubmed: 28053104
J Gen Virol. 1976 Sep;32(3):471-7
pubmed: 823294