Azithromycin and Doxycycline Resistance Profiles of U.S. Mycoplasma genitalium Strains and Their Association with Treatment Outcomes.
MICs
Mycoplasma genitalium
antibiotic resistance
antibiotics
antimicrobial agents
azithromycin
doxycycline
nongonococcal urethritis
Journal
Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564
Informations de publication
Date de publication:
19 10 2021
19 10 2021
Historique:
pubmed:
19
8
2021
medline:
17
11
2021
entrez:
18
8
2021
Statut:
ppublish
Résumé
Mycoplasma genitalium is a sexually transmitted bacterium associated with nongonococcal urethritis (NGU) in men and cervicitis, endometritis, and pelvic inflammatory disease in women. Effective treatment is challenging due to the inherent, and increasingly acquired, antibiotic resistance in this pathogen. In our treatment trial conducted from 2007 to 2011 in Seattle, WA, we demonstrated poor efficacy of azithromycin (AZM) and doxycycline (DOX) against M. genitalium among men with NGU. In the present study, we cultured M. genitalium from 74 of 80 (92.5%) PCR-positive men at enrollment (V-1) and defined the MICs of AZM (
Identifiants
pubmed: 34406799
doi: 10.1128/JCM.00819-21
pmc: PMC8525566
doi:
Substances chimiques
Anti-Bacterial Agents
0
Azithromycin
83905-01-5
Doxycycline
N12000U13O
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0081921Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007140
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI031448
Pays : United States
Organisme : NIH HHS
ID : U19AI31448
Pays : United States
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