Molecular mimicry between SARS-CoV-2 and the female reproductive system.
COVID-19
SARS-CoV-2
autoimmunity
epitopes
molecular mimicry
oogenesis
Journal
American journal of reproductive immunology (New York, N.Y. : 1989)
ISSN: 1600-0897
Titre abrégé: Am J Reprod Immunol
Pays: Denmark
ID NLM: 8912860
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
14
08
2021
received:
03
04
2021
accepted:
16
08
2021
pubmed:
19
8
2021
medline:
15
12
2021
entrez:
18
8
2021
Statut:
ppublish
Résumé
Oogenesis, the process of egg production by the ovary, involves a complex differentiation program leading to the production of functional oocytes. This process comprises a sequential pathway of steps that are finely regulated. The question related to SARS-CoV-2 infection and fertility has been evoked for several reasons, including the mechanism of molecular mimicry, which may contribute to female infertility by leading to the generation of deleterious autoantibodies, possibly contributing to the onset of an autoimmune disease in infected patients. The immunological potential of the peptides shared between SARS-CoV-2 spike glycoprotein and oogenesis-related proteins; Thus we planned a systematic study to improve our understanding of the possible effects of SARS-CoV-2 infection on female fertility using the angle of molecular mimicry as a starting point. A library of 82 human proteins linked to oogenesis was assembled at random from UniProtKB database using oogenesis, uterine receptivity, decidualization, and placentation as a key words. For the analyses, an artificial polyprotein was built by joining the 82 a sequences of the oogenesis-associated proteins. These were analyzed by searching the Immune Epitope DataBase for immunoreactive SARS-CoV-2 spike glycoprotein epitopes hosting the shared pentapeptides. SARS-CoV-2 spike glycoprotein was found to share 41 minimal immune determinants, that is, pentapeptides, with 27 human proteins that relate to oogenesis, uterine receptivity, decidualization, and placentation. All the shared pentapeptides that we identified, with the exception of four, are also present in SARS-CoV-2 spike glycoprotein-derived epitopes that have been experimentally validated as immunoreactive.
Identifiants
pubmed: 34407240
doi: 10.1111/aji.13494
pmc: PMC8420155
doi:
Substances chimiques
Epitopes
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13494Subventions
Organisme : the French Centre National de la Recherche Scientifique, Région Grand-Est
Organisme : the University of Strasbourg Institute for Advanced Study (USIAS) and the Interdisciplinary Thematic Institute 2021-2028 program of the University of Strasbourg, CNRS and Inserm
ID : ANR-10-IDEX-0002
Organisme : the University of Strasbourg Institute for Advanced Study (USIAS) and the Interdisciplinary Thematic Institute 2021-2028 program of the University of Strasbourg, CNRS and Inserm
ID : ANR-20-SFRI-0012
Organisme : TRANSAUTOPHAGY COST Action
ID : CA15138
Organisme : the Club francophone de l'autophagie (CFATG)
Organisme : European Regional Development Fund of the European Union in the framework of the INTERREG V Upper Rhine program
Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Clin Chim Acta. 2018 Aug;483:265-270
pubmed: 29750965
N Engl J Med. 2008 Feb 14;358(7):709-15
pubmed: 18272894
Mol Cell Biol. 2010 Jul;30(14):3661-71
pubmed: 20479125
Nature. 2009 Sep 17;461(7262):415-8
pubmed: 19727073
J Pediatr Adolesc Gynecol. 2015 Oct;28(5):286-91
pubmed: 26231608
Eur J Hum Genet. 2021 Sep;29(9):1396-1404
pubmed: 33495594
Crit Care. 2020 May 6;24(1):198
pubmed: 32375845
Dev Biol. 2006 Jun 1;294(1):161-7
pubmed: 16564520
Development. 2003 Jan;130(2):369-78
pubmed: 12466203
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
N Engl J Med. 2003 Oct 23;349(17):1614-27
pubmed: 14573733
Reprod Biomed Online. 2020 Aug;41(2):157-159
pubmed: 32466995
Mol Hum Reprod. 2004 Jun;10(6):373-81
pubmed: 15044608
Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16595-600
pubmed: 20823249
J Reprod Dev. 2016 Dec 20;62(6):537-545
pubmed: 27478063
J Neuroendocrinol. 2013 Nov;25(11):991-1001
pubmed: 23763432
J Cell Biol. 2012 Jul 23;198(2):165-72
pubmed: 22826121
EMBO J. 1999 Feb 15;18(4):934-48
pubmed: 10022836
Int J Biol Sci. 2020 Mar 15;16(10):1724-1731
pubmed: 32226290
Nucleic Acids Res. 2020 Apr 17;48(7):3525-3541
pubmed: 32086523
Fertil Steril. 2020 Jun;113(6):1140-1149
pubmed: 32482250
Autoimmun Rev. 2021 Apr;20(4):102792
pubmed: 33610751
Nucleic Acids Res. 2018 Dec 14;46(22):12008-12021
pubmed: 30364987
Asian J Androl. 2017 Nov-Dec;19(6):619-624
pubmed: 28091399
Anticancer Agents Med Chem. 2015;15(10):1264-8
pubmed: 26179265
J Reprod Immunol. 1997 Jul;33(3):239-56
pubmed: 9255726
Autophagy. 2020 Dec;16(12):2260-2266
pubmed: 32522067
Sci Rep. 2019 Jul 3;9(1):9641
pubmed: 31270345
Curr Biol. 2008 Dec 23;18(24):1986-92
pubmed: 19062278
Am J Hum Genet. 1998 Mar;62(3):533-41
pubmed: 9497258
Mol Cell. 2017 Oct 19;68(2):374-387.e12
pubmed: 29033321
J Biol Chem. 2007 Oct 26;282(43):31725-32
pubmed: 17711857
Mol Hum Reprod. 2020 Jun 1;26(6):367-373
pubmed: 32365180
FASEB J. 1998 Oct;12(13):1255-65
pubmed: 9761770
J Reprod Dev. 2018 Dec 14;64(6):469-476
pubmed: 30298825
Am J Hum Genet. 2021 Feb 4;108(2):324-336
pubmed: 33508233
Gene. 2017 Sep 5;627:337-342
pubmed: 28669924
Curr Protein Pept Sci. 2013 Mar;14(2):111-20
pubmed: 23305312
Reprod Biomed Online. 2010 Nov;21(5):602-9
pubmed: 20864414
Placenta. 2011 Aug;32(8):619-21
pubmed: 21669459
Int J Biol Sci. 2019 Jan 29;15(4):726-737
pubmed: 30906205
Endocrinology. 2017 Dec 1;158(12):4270-4285
pubmed: 28938400
Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515
pubmed: 30395287
Sci Adv. 2020 Sep 2;6(36):
pubmed: 32917591
Front Immunol. 2021 Feb 19;12:641164
pubmed: 33679804
Syst Biol Reprod Med. 2021 Feb;67(1):3-23
pubmed: 33719829
Front Endocrinol (Lausanne). 2018 Jan 04;8:365
pubmed: 29354093
Hum Reprod. 2011 Apr;26(4):748-57
pubmed: 21321049
J Autoimmun. 2012 May;38(2-3):J266-74
pubmed: 22284905
J Autoimmun. 2018 Dec;95:100-123
pubmed: 30509385
Dev Biol. 2011 Aug 1;356(1):63-70
pubmed: 21621532
J Proteome Res. 2009 Nov;8(11):4983-92
pubmed: 19764806
PLoS Biol. 2010 Aug 17;8(8):
pubmed: 20808952
Mol Reprod Dev. 2011 Oct-Nov;78(10-11):831-45
pubmed: 21681843
Nucleic Acids Res. 2019 Jan 8;47(D1):D339-D343
pubmed: 30357391
Sci Rep. 2013;3:1462
pubmed: 23492904
Biochim Biophys Acta. 2012 Dec;1822(12):1896-912
pubmed: 22634430
BMJ Open. 2021 Feb 25;11(2):e045524
pubmed: 33632754
Sci Rep. 2016 Feb 04;6:20408
pubmed: 26842404
Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11250-11255
pubmed: 30333187
Br J Pharmacol. 2014 Feb;171(4):827-36
pubmed: 23889362
Arch Biochem Biophys. 2016 Sep 15;606:128-33
pubmed: 27477959
Antioxid Redox Signal. 2020 Mar 10;32(8):550-568
pubmed: 31892284
Philos Trans R Soc Lond B Biol Sci. 2016 Feb 19;371(1688):20150115
pubmed: 26833836
Hum Mol Genet. 1999 Jun;8(6):989-96
pubmed: 10332030
Mech Dev. 2000 May;93(1-2):221-31
pubmed: 10781961
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
Am J Hum Genet. 1998 Sep;63(3):794-802
pubmed: 9718346
Adv Exp Med Biol. 2014;759:33-56
pubmed: 25030759
Clin Rev Allergy Immunol. 2017 Aug;53(1):78-86
pubmed: 27628237
N Engl J Med. 2020 Apr 23;382(17):1653-1659
pubmed: 32227760
Am J Reprod Immunol. 2021 Dec;86(6):e13494
pubmed: 34407240
Nature. 2020 Aug;584(7822):646-651
pubmed: 32494015