Soft robotic steerable microcatheter for the endovascular treatment of cerebral disorders.
Animals
Biomedical Engineering
Calibration
Catheterization
Catheters
Cerebral Arteries
/ pathology
Computer Simulation
Elasticity
Embolization, Therapeutic
/ instrumentation
Endovascular Procedures
/ instrumentation
Equipment Design
Female
Humans
Imaging, Three-Dimensional
Intracranial Aneurysm
/ therapy
Polymers
Robotics
Swine
United States
Journal
Science robotics
ISSN: 2470-9476
Titre abrégé: Sci Robot
Pays: United States
ID NLM: 101733136
Informations de publication
Date de publication:
18 08 2021
18 08 2021
Historique:
received:
02
10
2020
accepted:
26
07
2021
entrez:
19
8
2021
pubmed:
20
8
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Catheters used for endovascular navigation in interventional procedures lack dexterity at the distal tip. Neurointerventionists, in particular, encounter challenges in up to 25% of aneurysm cases largely due to the inability to steer and navigate the tip of the microcatheters through tortuous vasculature to access aneurysms. We overcome this problem with submillimeter diameter, hydraulically actuated hyperelastic polymer devices at the distal tip of microcatheters to enable active steerability. Controlled by hand, the devices offer complete 3D orientation of the tip. Using saline as a working fluid, we demonstrate guidewire-free navigation, access, and coil deployment in vivo, offering safety, ease of use, and design flexibility absent in other approaches to endovascular intervention. We demonstrate the ability of our device to navigate through vessels and to deliver embolization coils to the cerebral vessels in a live porcine model. This indicates the potential for microhydraulic soft robotics to solve difficult access and treatment problems in endovascular intervention.
Identifiants
pubmed: 34408094
pii: 6/57/eabf0601
doi: 10.1126/scirobotics.abf0601
pmc: PMC9809155
mid: NIHMS1840728
pii:
doi:
Substances chimiques
Polymers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001442
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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