Nano lipidic carriers for codelivery of sorafenib and ganoderic acid for enhanced synergistic antitumor efficacy against hepatocellular carcinoma.

Antioxidants Hepatocellular carcinoma Inflammatory markers Nanolipdic carrier Nonhepatic parameters Sorafenib

Journal

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
ISSN: 1319-0164
Titre abrégé: Saudi Pharm J
Pays: Saudi Arabia
ID NLM: 9705695

Informations de publication

Date de publication:
Aug 2021
Historique:
received: 23 03 2021
accepted: 23 06 2021
entrez: 19 8 2021
pubmed: 20 8 2021
medline: 20 8 2021
Statut: ppublish

Résumé

The current study focuses on the development and evaluation of nano lipidic carriers (NLCs) for codelivery of sorafenib (SRF) and ganoderic acid (GA) therapy in order to treat hepatocellular carcinoma (HCC). The dual drug-loaded NLCs were prepared by hot microemulsion technique, where SRF and GA as the drugs, Precirol ATO5, Capmul PG8 as the lipids, while Solutol HS15 and ethanol was used as surfactant and cosolvents. The optimized drug-loaded NLCs were extensively characterized through

Identifiants

DOI: 10.1016/j.jsps.2021.06.006 PMID: 34408545 PMC: PMC8363106
pubmed: 34408545
doi: 10.1016/j.jsps.2021.06.006
pii: S1319-0164(21)00120-1
pmc: PMC8363106
doi:

Types de publication

Journal Article

Langues

eng

Pagination

843-856

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Références

Inflammopharmacology. 2018 Feb;26(1):133-146
pubmed: 28608141
Int J Pharm. 2011 Jul 29;414(1-2):267-75
pubmed: 21596122
Drug Deliv. 2016;23(1):214-29
pubmed: 24825490
Biochim Biophys Acta Rev Cancer. 2020 Aug;1874(1):188382
pubmed: 32522600
Nanomedicine (Lond). 2018 Dec;13(24):3107-3128
pubmed: 30474494
J Hepatol. 2006 Oct;45(4):529-38
pubmed: 16879891
Hepatology. 2008 Apr;47(4):1363-70
pubmed: 18366115
Drug Dev Ind Pharm. 2018 Mar;44(3):407-420
pubmed: 29048242
Int J Pharm. 2002 Aug 21;242(1-2):121-8
pubmed: 12176234
Int J Nanomedicine. 2017 Sep 11;12:6747-6758
pubmed: 28932118
Expert Rev Anticancer Ther. 2019 Feb;19(2):177-189
pubmed: 30575405
AAPS PharmSciTech. 2019 Jan 23;20(2):87
pubmed: 30675689
Biochim Biophys Acta Rev Cancer. 2020 Jan;1873(1):188314
pubmed: 31682895
Oncotarget. 2016 Jan 26;7(4):4860-70
pubmed: 26695439
Biomed Pharmacother. 2017 Oct;94:834-842
pubmed: 28802237
J Microencapsul. 2018 Jun;35(4):327-343
pubmed: 29873288
Int J Mol Med. 2018 Sep;42(3):1695-1715
pubmed: 29901131
Expert Opin Drug Deliv. 2021 Apr;18(4):489-513
pubmed: 33225771
Drug Deliv. 2019 Dec;26(1):782-793
pubmed: 31357897
Food Sci Nutr. 2020 Jun 15;8(8):4185-4195
pubmed: 32884699
Int J Pharm. 2021 Jan 5;592:120029
pubmed: 33130218
PLoS One. 2020 Dec 11;15(12):e0243815
pubmed: 33306731
Regul Toxicol Pharmacol. 2002 Aug;36(1):86-95
pubmed: 12383721
Drug Deliv. 2020 Dec;27(1):983-995
pubmed: 32611218
Nanomedicine (Lond). 2018 Apr;13(8):849-870
pubmed: 29565220
Acta Pharmacol Sin. 2017 May;38(5):614-622
pubmed: 28344323

Auteurs

Bin Wang (B)

Department of Oncology Minimally Invasive, The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences), Jinan, Shandong Province 250031, China.

Lin Sun (L)

Department of Radiology, Binzhou People's Hospital, Binzhou, Shandong Province 256610, China.

Mingyun Wen (M)

Department of Radiology, Binzhou People's Hospital, Binzhou, Shandong Province 256610, China.

Youchun Tan (Y)

Department of Hepatobiliary Surgery, Shandong Provincial Third Hospital, Cheeloo College of Medicne, Shandong University, No.11 Wuying Shanzhong Road, Jinan City, Shandong Province 250031, China.

Waleed H Almalki (WH)

Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.

Hanadi Katouah (H)

Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.

Imran Kazmi (I)

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Obaid Afzal (O)

Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, AlKharj, Saudi Arabia.

Abdulmalik Saleh Alfawaz Altamimi (ASA)

Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, AlKharj, Saudi Arabia.

Fahad A Al-Abbasi (FA)

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Majed Alrobaian (M)

Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.

Khalid S Alharbi (KS)

Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia.

Sattam K Alenezi (SK)

Department of Pharmacology & Toxicology, Unaizah College of Pharmacy, Qassim University, Qassim, Saudi Arabia.

Adel F Alghaith (AF)

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Sarwar Beg (S)

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

Mahfoozur Rahman (M)

Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, India.

Classifications MeSH