Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β Load.

18F-florbetaben PET amyloid biomarkers cognitively normal preclinical Alzheimer's disease subjective cognitive decline

Journal

Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824

Informations de publication

Date de publication:
2021
Historique:
received: 03 03 2021
accepted: 22 06 2021
entrez: 19 8 2021
pubmed: 20 8 2021
medline: 20 8 2021
Statut: epublish

Résumé

Subjective cognitive decline (SCD) is considered an early risk stage for dementia due to Alzheimer's disease (AD) and the development of pathological brain changes, such as the aggregation of amyloid-beta (amyloid-β) plaques. This study evaluates the association between specific features of SCD and cerebral amyloid-β load measured by positron emission tomography (PET) with

Identifiants

DOI: 10.3389/fnagi.2021.675583 PMID: 34408640 PMC: PMC8365025
pubmed: 34408640
doi: 10.3389/fnagi.2021.675583
pmc: PMC8365025
doi:

Types de publication

Journal Article

Langues

eng

Pagination

675583

Informations de copyright

Copyright © 2021 Schwarz, Lange, Benson, Horn, Wurdack, Lukas, Buchert, Wirth and Flöel.

Déclaration de conflit d'intérêts

AF has obtained consulting fees from Bayer and Biogen Idec., honoraria for oral presentations from Novartis, Roche, Daiichi Sankyo, Biogen Idec, and DrSchär AG, as well as royalties from the book Alzheimer-Unabwendbares Schicksal? ML was employed by the company Siemens Healthcare GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Claudia Schwarz (C)

Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Catharina Lange (C)

Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Gloria S Benson (GS)

Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Nora Horn (N)

Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Katharina Wurdack (K)

Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Mathias Lukas (M)

Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Siemens Healthcare GmbH, Berlin, Germany.

Ralph Buchert (R)

Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Department for Diagnostic and Interventional Radiology and Nuclear Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Miranka Wirth (M)

German Center for Neurodegenerative Diseases (DZNE) Site: Dresden, Dresden, Germany.

Agnes Flöel (A)

Department of Neurology, University Medicine Greifswald, Greifswald, Germany.
German Center for Neurodegenerative Diseases (DZNE) Site: Greifswald, Greifswald, Germany.

Classifications MeSH