Long Noncoding RNAs as Emerging Regulators of COVID-19.
Antiviral Agents
/ pharmacology
Biomarkers
/ analysis
COVID-19
/ complications
COVID-19 Testing
/ methods
Cytokines
/ genetics
Gene Expression Regulation, Viral
/ drug effects
Host Microbial Interactions
/ drug effects
Humans
Immune Evasion
/ genetics
Immunity, Innate
/ genetics
Pandemics
/ prevention & control
RNA, Long Noncoding
/ analysis
SARS-CoV-2
/ drug effects
Signal Transduction
/ genetics
Thrombosis
/ genetics
Virus Replication
/ drug effects
COVID-19 Drug Treatment
COVID-19
SARS-CoV-2
immune responses
lncRNAs
virus infections
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
05
2021
accepted:
15
07
2021
entrez:
19
8
2021
pubmed:
20
8
2021
medline:
25
8
2021
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-19), which has high incidence rates with rapid rate of transmission, is a pandemic that spread across the world, resulting in more than 3,000,000 deaths globally. Currently, several drugs have been used for the clinical treatment of COVID-19, such as antivirals (radecivir, baritinib), monoclonal antibodies (tocilizumab), and glucocorticoids (dexamethasone). Accumulating evidence indicates that long noncoding RNAs (lncRNAs) are essential regulators of virus infections and antiviral immune responses including biological processes that are involved in the regulation of COVID-19 and subsequent disease states. Upon viral infections, cellular lncRNAs directly regulate viral genes and influence viral replication and pathology through virus-mediated changes in the host transcriptome. Additionally, several host lncRNAs could help the occurrence of viral immune escape by inhibiting type I interferons (IFN-1), while others could up-regulate IFN-1 production to play an antiviral role. Consequently, understanding the expression and function of lncRNAs during severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection will provide insights into the development of lncRNA-based methods. In this review, we summarized the current findings of lncRNAs in the regulation of the strong inflammatory response, immune dysfunction and thrombosis induced by SARS-CoV-2 infection, discussed the underlying mechanisms, and highlighted the therapeutic challenges of COVID-19 treatment and its future research directions.
Identifiants
pubmed: 34408749
doi: 10.3389/fimmu.2021.700184
pmc: PMC8366413
doi:
Substances chimiques
Antiviral Agents
0
Biomarkers
0
Cytokines
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
700184Informations de copyright
Copyright © 2021 Yang, Lin, Wang, Zeng and Luo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
J Cell Mol Med. 2020 Jun;24(12):6558-6570
pubmed: 32320516
Arch Biochem Biophys. 2018 Jul 1;649:15-21
pubmed: 29704485
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Biomed Pharmacother. 2018 Jul;103:897-902
pubmed: 29710506
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
Cell Mol Life Sci. 2016 Jul;73(13):2491-509
pubmed: 27007508
J Biomol Struct Dyn. 2022 May;40(8):3681-3696
pubmed: 33228475
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
PLoS Negl Trop Dis. 2021 Jan 6;15(1):e0009051
pubmed: 33406076
Eur J Nucl Med Mol Imaging. 2020 May;47(5):1275-1280
pubmed: 32107577
Allergo J Int. 2021;30(2):51-55
pubmed: 33643776
Cancer Immunol Res. 2019 May;7(5):813-827
pubmed: 30914411
Science. 2020 Nov 13;370(6518):856-860
pubmed: 33082293
Nucleic Acids Res. 2019 Apr 8;47(6):3013-3027
pubmed: 30788509
J Med Virol. 2005 Feb;75(2):185-94
pubmed: 15602737
Mol Cell. 2014 Apr 24;54(2):273-80
pubmed: 24766891
Trends Microbiol. 2017 Nov;25(11):942-952
pubmed: 28522156
Nat Cell Biol. 2019 Apr;21(4):498-510
pubmed: 30936474
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
Int J Mol Sci. 2019 Jul 15;20(14):
pubmed: 31311130
mBio. 2010 Oct 26;1(5):
pubmed: 20978541
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):716-21
pubmed: 18184812
Allergy. 2021 Jun;76(6):1629-1639
pubmed: 33452689
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Noncoding RNA. 2019 Jan 14;5(1):
pubmed: 30646609
MMWR Morb Mortal Wkly Rep. 2021 Jan 15;70(2):46-51
pubmed: 33444297
Cell Host Microbe. 2014 Nov 12;16(5):616-26
pubmed: 25525793
Front Immunol. 2020 Oct 09;11:590870
pubmed: 33163005
J Cell Mol Med. 2021 May;25(10):4753-4764
pubmed: 33759345
J Neurovirol. 2018 Oct;24(5):597-605
pubmed: 29987580
J Virol. 2008 Aug;82(15):7264-75
pubmed: 18495771
J Cell Mol Med. 2021 Jun;25(12):5823-5827
pubmed: 33969601
Viruses. 2021 Mar 03;13(3):
pubmed: 33802569
ACS Chem Neurosci. 2020 May 6;11(9):1206-1209
pubmed: 32320211
Br J Haematol. 2020 May;189(3):428-437
pubmed: 32297671
Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-2261
pubmed: 32253535
Emerg Microbes Infect. 2020 Dec;9(1):558-570
pubmed: 32172672
Mediators Inflamm. 2021 Apr 1;2021:6635925
pubmed: 33833618
Inflammation. 2019 Aug;42(4):1139-1146
pubmed: 30825076
Eur Rev Med Pharmacol Sci. 2019 Oct;23(19):8403-8410
pubmed: 31646570
Life Sci. 2021 Feb 1;266:118883
pubmed: 33316266
Nature. 2011 Jan 20;469(7330):343-9
pubmed: 21248841
Viruses. 2010 Aug;2(8):1804-1820
pubmed: 21994708
Curr Top Microbiol Immunol. 2005;287:1-30
pubmed: 15609507
Immunol Rev. 2013 Sep;255(1):197-209
pubmed: 23947356
N Engl J Med. 2021 May 20;384(20):1964-1965
pubmed: 33852795
Biomed Pharmacother. 2020 Oct;130:110548
pubmed: 33475497
Intensive Care Med. 2020 May;46(5):846-848
pubmed: 32125452
ACS Chem Neurosci. 2020 Apr 1;11(7):995-998
pubmed: 32167747
Exp Ther Med. 2020 Oct;20(4):3138-3146
pubmed: 32855682
Pathogens. 2020 Mar 04;9(3):
pubmed: 32143502
Travel Med Infect Dis. 2020 Jul - Aug;36:101642
pubmed: 32220634
Cells. 2020 Oct 29;9(11):
pubmed: 33138195
J Thromb Haemost. 2018 Feb;16(2):231-241
pubmed: 29193703
Cancer Biol Ther. 2019;20(5):583-592
pubmed: 30739532
Mol Cell. 2014 Feb 6;53(3):393-406
pubmed: 24507715
J Exp Clin Cancer Res. 2019 May 9;38(1):189
pubmed: 31072375
Int J Biol Sci. 2020 Mar 15;16(10):1686-1697
pubmed: 32226286
Front Bioeng Biotechnol. 2021 Jan 15;8:582953
pubmed: 33520952
Cancer Sci. 2020 Aug;111(8):2672-2681
pubmed: 32485023
J Thromb Haemost. 2020 Sep;18(9):2103-2109
pubmed: 32558075
Genome Biol. 2020 Sep 1;21(1):228
pubmed: 32873321
Physiol Rev. 2016 Oct;96(4):1297-325
pubmed: 27535639
Bioessays. 2021 May;43(5):e2000245
pubmed: 33748979
Curr Opin Genet Dev. 2020 Dec;65:42-46
pubmed: 32554106
Theranostics. 2020 Jun 19;10(17):7821-7835
pubmed: 32685022
Front Immunol. 2020 Jun 26;11:1580
pubmed: 32670297
Life Sci. 2020 Sep 15;257:118114
pubmed: 32693241
Blood. 2005 Oct 1;106(7):2366-74
pubmed: 15860669
Front Immunol. 2020 Dec 10;11:598444
pubmed: 33362782
Annu Rev Genet. 2017 Nov 27;51:385-411
pubmed: 28934594
Cancer Control. 2018 Jan-Mar;25(1):1073274818769849
pubmed: 29651883
Cytokine Growth Factor Rev. 2020 Jun;53:38-42
pubmed: 32360420
BMJ. 2020 Mar 26;368:m1091
pubmed: 32217556
Signal Transduct Target Ther. 2020 May 29;5(1):84
pubmed: 32467561
Signal Transduct Target Ther. 2020 Jun 10;5(1):89
pubmed: 32533062
Mol Cell. 2015 Feb 5;57(3):552-8
pubmed: 25601759
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23695-23706
pubmed: 32907941
Biochimie. 2021 Jan;180:169-177
pubmed: 33189832
Trends Microbiol. 2016 Jun;24(6):490-502
pubmed: 27012512
Gene. 2020 Dec 15;762:145057
pubmed: 32805314
ACS Chem Neurosci. 2020 Apr 15;11(8):1192-1194
pubmed: 32233443
J Virol. 2011 Jan;85(2):873-82
pubmed: 21068237
Signal Transduct Target Ther. 2020 Sep 2;5(1):180
pubmed: 32879307
Genome Res. 2012 Sep;22(9):1760-74
pubmed: 22955987
J Infect. 2020 Jul;81(1):e61-e66
pubmed: 32335173
Signal Transduct Target Ther. 2020 Dec 24;5(1):294
pubmed: 33361761
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Feb 10;41(2):145-151
pubmed: 32064853
Inflammopharmacology. 2021 Feb;29(1):91-100
pubmed: 33159646
Nat Microbiol. 2020 Apr;5(4):536-544
pubmed: 32123347
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Cell Rep. 2019 Jun 11;27(11):3295-3304.e4
pubmed: 31189112
Front Immunol. 2020 May 01;11:827
pubmed: 32425950
Exp Biol Med (Maywood). 2009 Oct;234(10):1117-27
pubmed: 19546349
Mol Cell. 2019 Dec 5;76(5):826-837.e11
pubmed: 31607545
Annu Rev Immunol. 2019 Apr 26;37:349-375
pubmed: 30673536
RNA Biol. 2014;11(7):875-90
pubmed: 24922324
Genes (Basel). 2020 Jul 07;11(7):
pubmed: 32646047
Cureus. 2021 Feb 18;13(2):e13426
pubmed: 33758714
Pathogens. 2020 Oct 24;9(11):
pubmed: 33114356
Annu Rev Microbiol. 2019 Sep 8;73:529-557
pubmed: 31226023
EBioMedicine. 2020 May;55:102763
pubmed: 32361250
Aust Prescr. 2021 Feb;44(1):19-25
pubmed: 33664546
Nature. 2021 Apr;592(7854):334-335
pubmed: 33846607
Nature. 2009 Mar 12;458(7235):223-7
pubmed: 19182780
Nat Commun. 2020 Jul 30;11(1):3810
pubmed: 32733001
Nat Genet. 2015 Mar;47(3):199-208
pubmed: 25599403
Front Cell Infect Microbiol. 2020 Oct 22;10:563850
pubmed: 33194802
Lancet Neurol. 2020 Sep;19(9):767-783
pubmed: 32622375
Viruses. 2020 Dec 30;13(1):
pubmed: 33396605
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Int J Infect Dis. 2020 Feb;91:264-266
pubmed: 31953166
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Nat Med. 2016 Feb;22(2):128-34
pubmed: 26845405
Alzheimers Res Ther. 2020 Jun 4;12(1):69
pubmed: 32498691
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Chest. 2019 Mar;155(3):587-594
pubmed: 30392791
Immunity. 2020 Jun 16;52(6):971-977.e3
pubmed: 32413330
Mol Ther Nucleic Acids. 2019 Dec 6;18:285-297
pubmed: 31604167
Lancet Respir Med. 2020 May;8(5):475-481
pubmed: 32105632
HIV Med. 2016 Jan;17(1):68-72
pubmed: 26139386
Acta Pharmacol Sin. 2020 Dec;41(12):1539-1546
pubmed: 33110240
Genes Dev. 2019 Jun 1;33(11-12):656-668
pubmed: 30923168
Sci Rep. 2021 Apr 12;11(1):7991
pubmed: 33846375
Front Immunol. 2020 Sep 25;11:569524
pubmed: 33101288
Nat Commun. 2019 Apr 2;10(1):1495
pubmed: 30940803
Mol Cell. 2017 Aug 3;67(3):387-399.e5
pubmed: 28712728
PLoS Genet. 2013 Mar;9(3):e1003368
pubmed: 23555285
Nature. 2020 Mar;579(7798):265-269
pubmed: 32015508