Bioengineering the Cardiac Conduction System: Advances in Cellular, Gene, and Tissue Engineering for Heart Rhythm Regeneration.

bioengineering biological pacemaker cardiac conduction system cardiac diseases gene engineering tissue engineering

Journal

Frontiers in bioengineering and biotechnology

ISSN: 2296-4185

Titre abrégé: Front Bioeng Biotechnol

Pays: Switzerland

ID NLM: 101632513

Informations de publication

Date de publication:
2021

Historique:

received: 27 02 2021

accepted: 24 06 2021

entrez: 19 8 2021

pubmed: 20 8 2021

medline: 20 8 2021

Statut: epublish

Résumé

Heart rhythm disturbances caused by different etiologies may affect pediatric and adult patients with life-threatening consequences. When pharmacological therapy is ineffective in treating the disturbances, the implantation of electronic devices to control and/or restore normal heart pacing is a unique clinical management option. Although these artificial devices are life-saving, they display many limitations; not least, they do not have any capability to adapt to somatic growth or respond to neuroautonomic physiological changes. A biological pacemaker could offer a new clinical solution for restoring heart rhythms in the conditions of disorder in the cardiac conduction system. Several experimental approaches, such as cell-based, gene-based approaches, and the combination of both, for the generation of biological pacemakers are currently established and widely studied. Pacemaker bioengineering is also emerging as a technology to regenerate nodal tissues. This review analyzes and summarizes the strategies applied so far for the development of biological pacemakers, and discusses current translational challenges toward the first-in-human clinical application.

Identifiants

DOI: 10.3389/fbioe.2021.673477 PMID: 34409019 PMC: PMC8365186

pubmed: 34409019

doi: 10.3389/fbioe.2021.673477

pmc: PMC8365186

doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

673477

Informations de copyright

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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