Sarcoid-Associated Bilateral Multifocal Choroiditis Secondary to Adalimumab.
Adalimumab
Drug reaction
Multifocal choroiditis
Sarcoidosis
Tumor necrosis factor alpha inhibitor
Uveitis
Journal
Journal of current ophthalmology
ISSN: 2452-2325
Titre abrégé: J Curr Ophthalmol
Pays: India
ID NLM: 101678509
Informations de publication
Date de publication:
Historique:
received:
13
10
2020
revised:
24
12
2020
accepted:
04
02
2021
entrez:
19
8
2021
pubmed:
20
8
2021
medline:
20
8
2021
Statut:
epublish
Résumé
To report a rare paradoxical development of systemic sarcoidosis in a patient taking adalimumab manifesting as multifocal choroidal infiltrates and seventh nerve palsy. This was a single patient case report. A 30-year-old man with a history of psoriatic arthritis on adalimumab presented with intermittent fevers and headaches. Initial infectious serology and initial ophthalmic examination were within normal limits. Over the next month, he developed a seventh nerve palsy, unilateral decreased visual acuity, and bilateral multifocal choroidal infiltrates. The patient was diagnosed with systemic sarcoidosis secondary to tumor necrosis factor alpha (TNFα) inhibitor use after a hilar lymph node biopsy. Upon treatment with high-dose oral corticosteroids, the patient's symptoms and choroidal lesions significantly improved. This case report illustrates a rare presentation of ocular, neurologic, and systemic sarcoidosis presenting as a bilateral multifocal choroiditis and seventh nerve paresis in a patient treated with adalimumab. We highlight the importance of obtaining an ophthalmic evaluation in the management of this rare adverse effect of TNFα inhibitors.
Identifiants
pubmed: 34409234
doi: 10.4103/2452-2325.312161
pii: JCO-33-205
pmc: PMC8365578
doi:
Types de publication
Case Reports
Langues
eng
Pagination
205-208Informations de copyright
Copyright: © 2021 Journal of Current Ophthalmology.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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