Patterns of Autofluorescence in Common Genotypes of Retinitis Pigmentosa.
Journal
Ophthalmic surgery, lasers & imaging retina
ISSN: 2325-8179
Titre abrégé: Ophthalmic Surg Lasers Imaging Retina
Pays: United States
ID NLM: 101599215
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
entrez:
19
8
2021
pubmed:
20
8
2021
medline:
25
11
2021
Statut:
ppublish
Résumé
To investigate whether different forms of retinitis pigmentosa (RP) could be distinguished from one another using fundus autofluorescence (FAF) imaging. The National Institutes of Health EyeGene database was used to gather FAF images from 31 patients with RP, which were separated into 11 groups based on the RP-associated gene that was mutated. Investigators reviewed the images for patterns of autofluorescence (AF) and recorded qualitative observations. Four patterns of AF were noted within the macula, including central foveal hyper AF, a perifoveal hyper AF ring, a macular hyper AF ring, and a bull's-eye pattern of AF. Four patterns of AF were noted outside of the macula, including a mid-peripheral hyper AF ring, extramacular spots of hyper AF, patches of hypo AF, and diffuse hypo AF in the periphery. Double hyper AF rings were present in Similar patterns of AF were seen in different forms of RP, and AF failed to distinguish different genotypes.
Sections du résumé
BACKGROUND AND OBJECTIVE
To investigate whether different forms of retinitis pigmentosa (RP) could be distinguished from one another using fundus autofluorescence (FAF) imaging.
PATIENTS AND METHODS
The National Institutes of Health EyeGene database was used to gather FAF images from 31 patients with RP, which were separated into 11 groups based on the RP-associated gene that was mutated. Investigators reviewed the images for patterns of autofluorescence (AF) and recorded qualitative observations.
RESULTS
Four patterns of AF were noted within the macula, including central foveal hyper AF, a perifoveal hyper AF ring, a macular hyper AF ring, and a bull's-eye pattern of AF. Four patterns of AF were noted outside of the macula, including a mid-peripheral hyper AF ring, extramacular spots of hyper AF, patches of hypo AF, and diffuse hypo AF in the periphery. Double hyper AF rings were present in
CONCLUSIONS
Similar patterns of AF were seen in different forms of RP, and AF failed to distinguish different genotypes.
Identifiants
pubmed: 34410191
doi: 10.3928/23258160-20210727-03
doi:
Substances chimiques
Eye Proteins
0
RPGR protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM