Brief relaxation training is associated with long-term endocrine therapy adherence among women with breast cancer: post hoc analysis of a randomized controlled trial.
Adherence
Behavior change
Breast cancer
Endocrine therapy
Psycho-oncology
Journal
Breast cancer research and treatment
ISSN: 1573-7217
Titre abrégé: Breast Cancer Res Treat
Pays: Netherlands
ID NLM: 8111104
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
13
06
2021
accepted:
08
08
2021
pubmed:
20
8
2021
medline:
3
11
2021
entrez:
19
8
2021
Statut:
ppublish
Résumé
Despite life-saving potential, many women struggle to adhere to adjuvant endocrine therapy (AET) for their breast cancer (BCa). Prior research has demonstrated that emotional distress is a barrier to AET adherence. We followed women from a trial to test the long-term effects of two 5-week post-surgical group-based stress management interventions, cognitive behavioral therapy (CBT), and relaxation training versus an attention-matched health education control, on AET adherence. We conducted a long-term follow-up (median = 8 years) of women randomized to CBT, relaxation training, or health education after surgery for stage 0-3 BCa. We measured adherence with the Endocrine Therapy Medication Usage Questionnaire (ETMUQ). First, we established factors on the ETMUQ via confirmatory factor analysis. We then used Bayesian structural equation modeling to regress these factors on study arm, controlling for age and treatments received. Of those who completed long-term follow-up (n = 59, 44.7%), over half (n = 33; 55.9%) reported problems with adherence generally. Women receiving relaxation training (n = 15) had better adherence than those receiving health education (n = 24) on the Forgetfulness/Inconsistency [B(SE) = 0.25(0.14), p = 0.049] and Intentional Nonadherence [B(SE) = 0.31(0.14), p = 0.018] factors of the ETMUQ. Similar results were observed for those receiving relaxation training compared to CBT (n = 20): Forgetfulness/Inconsistency [B(SE) = - 0.47(0.25), p = 0.031]; Intentional Nonadherence [B(SE) = - 0.31(0.15), p = 0.027]. Women receiving relaxation training were less likely to (1) forget to take their AET and (2) intentionally miss doses of AET in the long term compared to women receiving health education or CBT. This is evidence for the need of randomized trials that aim to improve adherence by incorporating theoretically based behavioral change techniques. Trial 2R01-CA-064710 was registered March 26, 2006.
Identifiants
pubmed: 34410568
doi: 10.1007/s10549-021-06361-x
pii: 10.1007/s10549-021-06361-x
pmc: PMC9245682
mid: NIHMS1818420
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-88Subventions
Organisme : NCI NIH HHS
ID : F31CA254148-01
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA064710
Pays : United States
Organisme : NCI NIH HHS
ID : 2R01-CA-064710
Pays : United States
Organisme : NIDA NIH HHS
ID : K24 DA040489
Pays : United States
Organisme : NIH HHS
ID : 9K24DA040489
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA254148
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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