Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples.
Fosfomycin
LC-MS/MS
TDM
Therapeutic drug monitoring
UPLC
bioanalytical method validation
fosfomycin concentration
Journal
Journal of chemotherapy (Florence, Italy)
ISSN: 1973-9478
Titre abrégé: J Chemother
Pays: England
ID NLM: 8907348
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
pubmed:
20
8
2021
medline:
22
2
2022
entrez:
19
8
2021
Statut:
ppublish
Résumé
Individualization of fosfomycin dosing based on therapeutic drug monitoring (TDM) of plasma concentrations could reduce drug-related adverse events and improve clinical outcome in complex clinical conditions. Quantification of fosfomycin in plasma samples was performed by a rapid ultraperformance liquid chromatography mass spectrometry method. Sample preparation involved protein precipitation with [
Identifiants
pubmed: 34410896
doi: 10.1080/1120009X.2021.1963617
doi:
Substances chimiques
Anti-Bacterial Agents
0
Fosfomycin
2N81MY12TE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM