Neutrophil Gelatinase-associated Lipocalin Predicts Post-traumatic Acute Kidney Injury in Severely Injured Patients.
Acute kidney injury
LCN2
acute kidney failure
lipocalin 2
multiple trauma
multiple-organ dysfunction syndrome
multiple-organ failure
neutrophil gelatinase-associated lipocalin
Journal
In vivo (Athens, Greece)
ISSN: 1791-7549
Titre abrégé: In Vivo
Pays: Greece
ID NLM: 8806809
Informations de publication
Date de publication:
Historique:
received:
19
05
2021
revised:
02
07
2021
accepted:
08
07
2021
entrez:
19
8
2021
pubmed:
20
8
2021
medline:
24
8
2021
Statut:
ppublish
Résumé
Early detection of acute kidney injury (AKI) is crucial in the management of multiple-organ dysfunction syndrome in severely injured patients. Standard laboratory parameters usually increase with temporal delay. Therefore, we evaluated neutrophil gelatinase-associated lipocalin (NGAL) as an early marker for acute kidney injury. We retrospectively evaluated patients admitted to a level 1 trauma center. We collected clinicodemographic data and measured kidney-related factors and plasma cytokines. A total of 39 patients were included. Patients with AKI had significantly higher levels not only of serum creatinine and urea, but also of NGAL (all p<0.001) than patients without AKI. The optimal NGAL cut-off value was determined to be 177 ng/ml, showing significant correlation with imminent or manifest AKI (p<0.001). Other independent markers correlated with AKI included pre-existing chronic kidney disease, use of catecholamines, and severe injury (p<0.001). The serum level of NGAL is feasible early predictor of AKI.
Sections du résumé
BACKGROUND
BACKGROUND
Early detection of acute kidney injury (AKI) is crucial in the management of multiple-organ dysfunction syndrome in severely injured patients. Standard laboratory parameters usually increase with temporal delay. Therefore, we evaluated neutrophil gelatinase-associated lipocalin (NGAL) as an early marker for acute kidney injury.
PATIENTS AND METHODS
METHODS
We retrospectively evaluated patients admitted to a level 1 trauma center. We collected clinicodemographic data and measured kidney-related factors and plasma cytokines.
RESULTS
RESULTS
A total of 39 patients were included. Patients with AKI had significantly higher levels not only of serum creatinine and urea, but also of NGAL (all p<0.001) than patients without AKI. The optimal NGAL cut-off value was determined to be 177 ng/ml, showing significant correlation with imminent or manifest AKI (p<0.001). Other independent markers correlated with AKI included pre-existing chronic kidney disease, use of catecholamines, and severe injury (p<0.001).
CONCLUSION
CONCLUSIONS
The serum level of NGAL is feasible early predictor of AKI.
Identifiants
pubmed: 34410965
pii: 35/5/2755
doi: 10.21873/invivo.12560
pmc: PMC8408701
doi:
Substances chimiques
Acute-Phase Proteins
0
Biomarkers
0
Lipocalin-2
0
Lipocalins
0
Proto-Oncogene Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2755-2762Informations de copyright
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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