Global Chronic Total Occlusion Crossing Algorithm: JACC State-of-the-Art Review.

chronic total occlusion global percutaneous coronary intervention treatment algorithm

Journal

Journal of the American College of Cardiology
ISSN: 1558-3597
Titre abrégé: J Am Coll Cardiol
Pays: United States
ID NLM: 8301365

Informations de publication

Date de publication:
24 08 2021
Historique:
received: 19 03 2021
revised: 16 04 2021
accepted: 17 05 2021
entrez: 20 8 2021
pubmed: 21 8 2021
medline: 18 12 2021
Statut: ppublish

Résumé

The authors developed a global chronic total occlusion crossing algorithm following 10 steps: 1) dual angiography; 2) careful angiographic review focusing on proximal cap morphology, occlusion segment, distal vessel quality, and collateral circulation; 3) approaching proximal cap ambiguity using intravascular ultrasound, retrograde, and move-the-cap techniques; 4) approaching poor distal vessel quality using the retrograde approach and bifurcation at the distal cap by use of a dual-lumen catheter and intravascular ultrasound; 5) feasibility of retrograde crossing through grafts and septal and epicardial collateral vessels; 6) antegrade wiring strategies; 7) retrograde approach; 8) changing strategy when failing to achieve progress; 9) considering performing an investment procedure if crossing attempts fail; and 10) stopping when reaching high radiation or contrast dose or in case of long procedural time, occurrence of a serious complication, operator and patient fatigue, or lack of expertise or equipment. This algorithm can improve outcomes and expand discussion, research, and collaboration.

Identifiants

pubmed: 34412818
pii: S0735-1097(21)05485-1
doi: 10.1016/j.jacc.2021.05.055
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

840-853

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Funding Support and Author Disclosures Dr Wu has received research funding from Abiomed, OrbusNeich, Asahi Intecc; has received consulting honoraria from Boston Scientific and Abbott Vascular; is a member of the board of directors for APCTO Club; and holds stock in Abbott Vascular. Dr Brilakis has received consulting and speaker honoraria from Abbott Vascular, the American Heart Association (associate editor, Circulation), Amgen, Biotronik, Boston Scientific, Cardiovascular Innovations Foundation (board of directors), ControlRad, CSI, Ebix, Elsevier, GE Healthcare, InfraRedx, Medtronic, Siemens, and Teleflex; has received research support from Regeneron and Siemens; is an owner of Hippocrates; and is a shareholder in MHI Ventures. Dr Mashayekhi has received consulting, speaker, and proctoring honoraria from Abbott Vascular, Asahi Intecc, AstraZeneca, Biotronik, Boston Scientific, Cardinal Health, Daiichi-Sankyo, Medtronic, Teleflex, and Terumo. Dr Tsuchikane is a consultant for Boston Scientific, Asahi Intecc, Nipro, and Kaneka. Dr Avran has received consulting, speaker, and proctoring honoraria from Asahi Intecc, Biotronik, Boston Scientific, Terumo, Alvimedica, and OrbusNeich. Dr Azzalini has received consulting fees from Abiomed and Teleflex. Dr Buller is global medical director of Teleflex. Dr Burke is a shareholder in Egg Medical and MHI Ventures. Dr Croce has received grants from Abbott, Takeda, Teleflex, and CSI; has received consulting honoraria from Abbott, BSCI, Biotronik, Philips, Abiomed, CSI, Takeda, and Cordis; and holds stock in Dyad Medical. Dr Damas de los Santos is a proctor, speaker, and consultant for Boston Scientific, Terumo, Abbott Vascular, and Biotronik. Dr Dens has consultancy contracts with Abbott, Boston Scientific, IMDS, Terumo, Topmedical (a distributor for Asahi); and is a chronic total occlusion proctor for Boston Scientific and Topmedical (Asahi). Dr di Mario has received research grants from Abbott, Amgen, Behring, Daiichi-Sankyo, Edwards, Medtronic, and Shockwave Medical. Dr Egred has received chronic total occlusion proctorship fees, speaker fees, honoraria, and grants from Abbott Vascular, Boston Scientific, Philips, Spectranetics, Vascular Perspectives, Merrill, Biotronik, and AstraZeneca. Dr Elbarouni has received speaker fees from Teleflex and Bayer. Dr ElGuindy has received consulting, speaker, and proctoring honoraria from Medtronic, Boston Scientific, Asahi Intecc, and Terumo. Dr Escaned has received personal fees from Abbott, Boston Scientific, Terumo, and Phillips. Dr Furkalo has a proctoring agreement with Medtronic; and has received speaker honoraria from Sanofi. Dr Garbo is a proctor and consultant for Philips Volcano, Boston Europe, Terumo Italy, and Europe Teleflex. Dr Hall has received speaker honoraria from Medtronic, OpSens Medical, and the Cardiovascular Innovations Foundation. Dr Hanna Quesada has received honoraria from Boston Scientific. Dr Harb is a consultant for Medtronic and Cardinal Health; and has received speaker honoraria from Cardinal Health and Terumo. Dr Harding has received speaker and consultancy fees from Boston Scientific, Medtronic, Bio-Excel, and Asahi Intecc. Dr Hatem is a member of the Speakers Bureau for Abbott, Boston Scientific, and Teleflex. Dr Hoye has received speaker fees from AstraZeneca and Sanofi. Dr Jaber has received proctoring fees from Abbott; and has received consulting, advisory board, and institutional funds from Medtronic. Dr Jaffer conducts sponsored research for Canon, Siemens, Teleflex, and Shockwave; is a consultant for Boston Scientific, Siemens, Biotronik, and Magenta Medical; and holds equity interest in Intravascular Imaging. Dr Jussila has a proctoring contract with Boston Scientific and EPS Vascular. Dr Kalyanasundaram has received fees from Abbott Vascular, Boston Scientific, Asahi Intecc, and Terumo. Dr Kandzari has received institutional research grant support from Abbott, Biotronik, Boston Scientific, Cardiovascular Systems, Medtronic, Teleflex, and OrbusNeich; Dr Karmpaliotis has received honoraria from Abbott Vascular and Boston Scientific; and holds equity in Saranas, Soundbite, and Traverse Vascular. Dr Kassem has received speaker honoraria from Boston Scientific, Abbott Vascular, GE, and Abiomed. Dr Khatri has received institutional research grant from Asahi Intecc and honoraria or consulting fees from Abbott Vascular, Boston Scientific, and Terumo. Dr Kornowski is a founder of NitiLoop. Dr Lamelas has received proctoring fees from Boston Scientific, Edwards Lifesciences, and Medtronic. Dr Lim has received educational support and honoraria from Asahi Intecc, Boston Scientific, Abbott Vascular, Kaneka, Biotronik, Alvimedica, Terumo, and Medtronic. Dr Lo has received speaker and proctoring honoraria from Bio-Excel, Boston Scientific, Abbott, and Terumo; and is a member of Medtronic’s advisory board. Dr Lombardi has received royalties and is a consultant for Asahi Intecc; is a consultant for Abiomed, Boston Scientific, Medtronic, Siemens, and Teleflex; and his spouse is an employee of Philips. Dr Maran is a consultant for Boston Scientific, Medtronic, and Philips. Dr Moses has received funding from Orchestra Biomedical and Ostial Corporation. Dr Munawar has received speaker and proctorship honoraria from Asahi Intecc, Terumo, Boston Scientific, Abbott Vascular, Toray, and Phillips. Dr Oksnes has proctoring contracts with Boston Scientific and EPS Vascular. Dr Olivecrona has received lecture honoraria from Abbott and Biotronik; and has received proctoring honoraria from EPS Vascular and Terumo. Dr Patel is a consultant for Abbott Vascular, Terumo, and Chiesi; and is a proctor for Medtronic. Dr Quadros has received honoraria from Boston Scientific; and has received research funding from Boston and Terumo. Dr Abi Rafeh is a proctor and consultant for Boston Scientific, Abbott, and Shockwave Medical. Dr Råmunddal has received consulting honoraria from EPS Vascular, Boston Scientific, and Abbott Vascular. Dr Riley is an advisory board and Speakers Bureau member for and has received consulting honoraria from Boston Scientific, Asahi Intecc, and Medtronic. Dr Saghatelyan has received proctoring and speaker honoraria from Asahi Intecc and Terumo. Dr Spaedy is a consultant for Boston Scientific and Abbott Vascular. Dr Stone has received speaker or other honoraria from Cook and Terumo; is a consultant to Valfix, TherOx, Vascular Dynamics, Robocath, HeartFlow, Gore, Ablative Solutions, Miracor, Neovasc, V-Wave, Abiomed, Ancora, MAIA Pharmaceuticals, Vectorious, Reva, Matrizyme, Cardiomech, Elucid Bio, and Occlutech; and holds equity or options with Ancora, Cagent, Applied Therapeutics, the Biostar family of funds, SpectraWave, Orchestra Biomed, Aria, Cardiac Success, the MedFocus family of funds, and Valfix. Dr Tammam has a proctorship agreement with Terumo. Dr Tremmel has received honoraria from Abbott Vascular and Boston Scientific. Dr Wollmuth has received consulting, speaker, and proctoring honoraria from Abbott Vascular, Abiomed, Asahi Intecc, Biotronik, Boston Scientific, Cardiovascular Systems, Medtronic, and Philips. Dr Ybarra has received consulting and speaker fees from Abbott Vascular Canada and SoundBite Medical Solutions. Dr Yeh has received research grants from Abbott Vascular, AstraZeneca, Cook, BD Bard, Boston Scientific, Medtronic, and Philips; and is a consultant for Abbott Vascular, AstraZeneca, Boston Scientific, Edwards Lifesciences, Medtronic, Shockwave Medical, and Zoll. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Auteurs

Eugene B Wu (EB)

Prince of Wales Hospital, Chinese University Hong Kong, Hong Kong. Electronic address: cto.demon@gmail.com.

Emmanouil S Brilakis (ES)

Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA.

Kambis Mashayekhi (K)

Department of Cardiology and Angiology, II University Heart Center Freiburg, Bad Krozingen, Germany.

Etsuo Tsuchikane (E)

Toyohashi Heart Center, Aichi, Japan.

Khaldoon Alaswad (K)

Edith and Benson Ford Heart and Vascular Institute, Henry Ford Hospital, Henry Ford Health System, Wayne State University, Detroit, Michigan, USA.

Mario Araya (M)

Clinica Alemana, Hospital Militar de Santiago, Santiago, Chile.

Alexandre Avran (A)

Pasteur Clinic Essey-lès-Nancy, Essey-lès-Nancy, France.

Lorenzo Azzalini (L)

Division of Cardiology, VCU Health Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.

Avtandil M Babunashvili (AM)

Center of Endosurgery, Moscow, Russia.

Baktash Bayani (B)

Cardiology Department, Mehr Hospital, Mashhad, Iran.

Michael Behnes (M)

First Department of Medicine, University Medical Centre Mannheim, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany.

Ravinay Bhindi (R)

Royal North Shore Hospital, University of Sydney, Sydney, Australia.

Nicolas Boudou (N)

Interventional Cardiology, Clinique Saint Augustin, Bordeaux, France.

Marouane Boukhris (M)

Cardiology Department, Abderrahment Mami Hospital, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Nenad Z Bozinovic (NZ)

University Clinical Niš, Niš, Serbia.

Leszek Bryniarski (L)

II Department of Cardiology and Cardiovascular Interventions, Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland.

Alexander Bufe (A)

Heart Center Krefeld, University Witten/Herdecke, Witten, Germany.

Christopher E Buller (CE)

Teleflex, Markham, Ontario, Canada; St. Michael's Hospital, Toronto, Ontario, Canada.

M Nicholas Burke (MN)

Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA.

Achim Buttner (A)

St. Michael's Hospital, Toronto, Ontario, Canada.

Pedro Cardoso (P)

Santa Maria University Hospital, Lisbon Academic Medical Centre and Centro Cardiovascular da Universidade de Lisboa, Lisbon, Portugal.

Mauro Carlino (M)

Interventional Cardiology Unit, Cardio-Thoracic-Vascular Department, IRCCS, San Raffaele Scientific Institute, Milan, Italy.

Ji-Yan Chen (JY)

Guangdong General Hospital, Guangdong, China.

Evald Hoej Christiansen (EH)

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.

Antonio Colombo (A)

Cardiology, Humanitas University, Humanitas IRCCS, Rozzano, Milan, Italy.

Kevin Croce (K)

Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Felix Damas de Los Santos (FD)

Instituto Nacional de Cardiologia, Ignacio Chávez and Centro Medico ABC, Mexico City, Mexico.

Tony de Martini (T)

Advocate Heart Institute, Downers Grove, Illinois, USA.

Joseph Dens (J)

Hospital Oost-Limburg, Genk, Belgium.

Carlo di Mario (C)

Department of Clinical & Experimental Medicine, University Hospital Careggi, Florence, Italy.

Kefei Dou (K)

Research Center for Coronary Heart Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China.

Mohaned Egred (M)

Freeman Hospital & Newcastle University, Newcastle upon Tyne, UK.

Basem Elbarouni (B)

St. Boniface Hospital & University of Manitoba, Winnipeg, Manitoba, Canada.

Ahmed M ElGuindy (AM)

Department of Cardiology, Aswan Heart Centre, Magdi Yacoub Foundation, Aswan, Egypt.

Javier Escaned (J)

Hospital Clinico San Carlos, IdISSC, Complutense University of Madrid, Madrid, Spain.

Sergey Furkalo (S)

National Institute of Surgery and Transplantology NAMS, Kiev, Ukraine.

Andrea Gagnor (A)

Department of Invasive Cardiology, Maria Vittoria Hospital, Turin, Italy.

Alfredo R Galassi (AR)

Cardiovascular Medicine Department of PROMISE University of Palermo, Palermo, Italy.

Roberto Garbo (R)

Maria Pia Hospital, GVM Care & Research, Turin, Italy.

Gabriele Gasparini (G)

Department of Invasive Cardiology, Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy.

Junbo Ge (J)

Zhongshan Hospital, Fudan University, Shanghai, China.

Lei Ge (L)

Zhongshan Hospital, Fudan University, Shanghai, China.

Pravin Kumar Goel (PK)

Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Omer Goktekin (O)

Memorial Hospital, Istanbul, Turkey.

Nieves Gonzalo (N)

Interventional Cardiology, Hospital Clinico San Carlos, IdISSC, Universidad Complutense, Madrid, Spain.

Luca Grancini (L)

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

Allison Hall (A)

Eastern Health/Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

Franklin Leonardo Hanna Quesada (FL)

"Clinica Comfamiliar," Pereira, Colombia.

Colm Hanratty (C)

Belfast Health and Social Care Trust, Belfast, UK.

Stefan Harb (S)

Medical University of Graz, University Heart Center, Graz, Austria.

Scott A Harding (SA)

Wellington Hospital, Capital and Coast District Health Board, Wellington, New Zealand.

Raja Hatem (R)

Hôpital du Sacré-Coeur de Montréal Université de Montréal, Montréal, Québec, Canada.

Jose P S Henriques (JPS)

University of Amsterdam, Amsterdam, the Netherlands.

David Hildick-Smith (D)

Sussex Cardiac Centre, Brighton, UK.

Jonathan M Hill (JM)

King's College Hospital, London, UK.

Angela Hoye (A)

Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull, Hull, UK.

Wissam Jaber (W)

Emory University, Atlanta, Georgia, USA.

Farouc A Jaffer (FA)

Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Yangsoo Jang (Y)

Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Risto Jussila (R)

Interventional Cardiology, Helsinki Heart Hospital, Helsinki, Finland.

Artis Kalnins (A)

Clinic of Cardiovascular Diseases, Riga East Clinical University Hospital, Riga, Latvia.

Arun Kalyanasundaram (A)

Promed Hospital, Chennai, India.

David E Kandzari (DE)

Piedmont Heart Institute and Cardiovascular Services, Atlanta, Georgia, USA.

Hsien-Li Kao (HL)

Department of Internal Medicine, Cardiology Division, Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan.

Dimitri Karmpaliotis (D)

Columbia University, New York, New York, USA.

Hussien Heshmat Kassem (HH)

Kasr Alainy Medical School, Cairo University, Cairo, Egypt, and Fujairah Hospital, Ministry of Health, Fujairah, United Arab Emirates.

Jaikirshan Khatri (J)

Cleveland Clinic, Cleveland, Ohio, USA.

Paul Knaapen (P)

Heart Center of the Amsterdam University Medical Centers, Amsterdam, the Netherlands.

Ran Kornowski (R)

Department of Cardiology, Rabin Medical Center, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Oleg Krestyaninov (O)

Meshalkin Novosibirsk Research Institute, Novosibirsk, Russia.

A V Ganesh Kumar (AVG)

Department of Cardiology, Dr. L.H. Hiranandani Hospital, Mumbai, India.

Pablo Manuel Lamelas (PM)

Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina, and Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

Seung-Whan Lee (SW)

Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Thierry Lefevre (T)

Institut Cardiovasculaire Paris Sud, Hôpital Prive Jacques Cartier, Massy, France.

Raymond Leung (R)

C.K. Hui Heart Centre, Royal Alexandra Hospital, Edmonton, Alberta, Canada.

Yu Li (Y)

Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Yue Li (Y)

Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, China.

Soo-Teik Lim (ST)

National Heart Centre of Singapore, Singapore.

Sidney Lo (S)

Department of Cardiology, Liverpool Hospital and The University of New South Wales, Sydney, Australia.

William Lombardi (W)

University of Washington, Seattle, Washington, USA.

Anbukarasi Maran (A)

Medical University of South Carolina, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA.

Margaret McEntegart (M)

Golden Jubilee National Hospital, Glasgow, UK.

Jeffrey Moses (J)

NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA.

Muhammad Munawar (M)

Binawaluya Cardiac Center and Department of Cardiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, and Department of Cardiology, Faculty of Medicine, Universitas Gadjahmada, Yogyakarta, Indonesia.

Andres Navarro (A)

Hospital de los Valles, Hospital de Especialidades Eugenio Espejo, Universidad San Francisco de Quito, Quito, Ecuador.

Hung M Ngo (HM)

Choray University Hospital, Hochiminh City, Vietnam.

William Nicholson (W)

Emory Healthcare, Atlanta, Georgia, USA.

Anja Oksnes (A)

Heart Department, Haukeland University Hospital, Bergen, Norway.

Goran K Olivecrona (GK)

Department of Cardiology SUS-Lund, Lund University, Lund, Sweden.

Lucio Padilla (L)

Department of Interventional Cardiology and Endovascular Therapeutics, ICBA, Instituto Cardiovascular, Buenos Aires, Argentina.

Mitul Patel (M)

Division of Cardiovascular Medicine, University of California, San Diego, School of Medicine, San Diego, California, USA.

Ashish Pershad (A)

Chandler Regional Medical Center, Chandler, Arizona, USA.

Marin Postu (M)

Cardiology Department, University of Medicine and Pharmacy "Carol Davila," Institute of Cardiovascular Diseases "Prof Dr C.C. Iliescu," Bucharest, Romania.

Jie Qian (J)

Beijing Fuwai Hospital, Beijing, China.

Alexandre Quadros (A)

Interventional Cardiology Division and Post Graduate Course of Cardiology, Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, Brazil.

Nidal Abi Rafeh (NA)

St. George Hospital University Medical Center, Beirut, Lebanon, and North Oaks Healthcare System, Hammond, Louisiana, USA.

Truls Råmunddal (T)

Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Vithala Surya Prakasa Rao (VS)

Care Hospitals, Hyderabad, India.

Nicolaus Reifart (N)

Department of Cardiology, Main Taunus Heart Institute, Bad Soden, Germany.

Robert F Riley (RF)

The Christ Hospital Health Network, Cincinnati, Ohio, USA.

Stephane Rinfret (S)

McGill University Health Centre, Montréal, Québec, Canada.

Meruzhan Saghatelyan (M)

Nork Marash MC, Erebouni MC, Yerevan, Armenia.

George Sianos (G)

AHEPA University Hospital, Thessaloniki, Greece.

Elliot Smith (E)

Department of Cardiology, Barts Heart Centre, St. Bartholomew's Hospital, London, UK.

Anthony Spaedy (A)

Boone Hospital Center, Columbia, Missouri, USA.

James Spratt (J)

St. George's University Hospital NHS Foundation Trust, London, UK.

Gregg Stone (G)

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Julian W Strange (JW)

Bristol Royal Infirmary, University Hospital Bristol NHS Trust, Bristol, UK.

Khalid O Tammam (KO)

Department at the International Medical Center, Jeddah, Saudi Arabia.

Craig A Thompson (CA)

NYU Langone Medical Center, New York, New York, USA.

Aurel Toma (A)

Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.

Jennifer A Tremmel (JA)

Stanford University Medical Centre, Stanford, California, USA.

Ricardo Santiago Trinidad (RS)

PCI Cardiology Group, Bayamon, Puerto Rico, USA.

Imre Ungi (I)

University of Szeged, Department of Invasive Cardiology, Szeged, Hungary.

Minh Vo (M)

Royal Columbian Hospital, Vancouver, British Columbia, Canada.

Vu Hoang Vu (VH)

Heart Center University Medical Center, Ho Chi Minh City, Vietnam.

Simon Walsh (S)

Belfast Health and Social Care Trust, Belfast, UK.

Gerald Werner (G)

Medizinische Klinik I Klinikum Darmstadt, Darmstadt, Germany.

Jaroslaw Wojcik (J)

Hospital of Invasive Cardiology IKARDIA, Nałęczów/Lublin, Poland.

Jason Wollmuth (J)

Providence Heart and Vascular Institute, Portland, Oregon, USA.

Bo Xu (B)

Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China.

Masahisa Yamane (M)

Saitima St. Luke's International Hospital, Tokyo, Japan.

Luiz F Ybarra (LF)

London Health Sciences Centre, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

Robert W Yeh (RW)

Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Qi Zhang (Q)

Shanghai East Hospital, Tongji University, Shanghai, China.

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