Case Report: Acquired Disseminated BCG in the Context of a Delayed Immune Reconstitution After Hematological Malignancy.
Administration, Intravesical
Antineoplastic Combined Chemotherapy Protocols
/ adverse effects
Antitubercular Agents
/ therapeutic use
BCG Vaccine
/ administration & dosage
Hematologic Neoplasms
/ drug therapy
Host-Pathogen Interactions
Humans
Immune Reconstitution
Immunocompromised Host
Male
Middle Aged
Mycobacterium bovis
/ drug effects
Opportunistic Infections
/ drug therapy
Risk Factors
Treatment Outcome
Tuberculosis, Pulmonary
/ diagnosis
Urinary Bladder Neoplasms
/ drug therapy
BCG
BCGosis-susceptible PIDs
Immunodeficiency
case report
contamination
hematological malignancies
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
04
2021
accepted:
15
07
2021
entrez:
20
8
2021
pubmed:
21
8
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Disseminated infections due to We report one case of severe disseminated BCG disease occurring after hematological malignancy in a 48-year-old man without BCG instillation and previously vaccinated in infancy with no complication. Laboratory investigations demonstrated that he was not affected by any known or candidate gene of IEI or intrinsic cellular defect involving IFNγ pathway. Whole genome sequencing of the BCG strain showed that it was most closely related to the This case highlights the fact that, in addition to the IEI, physicians, as well as microbiologists and pharmacists should be aware of possible acquired disseminated BCG disease in secondary immunocompromised patients treated in centers that administrate BCG for bladder cancers.
Identifiants
pubmed: 34413849
doi: 10.3389/fimmu.2021.696268
pmc: PMC8369751
doi:
Substances chimiques
Antitubercular Agents
0
BCG Vaccine
0
Types de publication
Case Reports
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
696268Informations de copyright
Copyright © 2021 Gies, Dieudonné, Morel, Sougakoff, Carapito, Martin, Weingertner, Jacquel, Hubele, Kuhnert, Jung, Schramm, Boyer, Hansmann, Danion, Korganow and Guffroy.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell. 2013 Oct 24;155(3):505-14
pubmed: 24243010
N Engl J Med. 1995 Aug 31;333(9):561-3
pubmed: 7623905
Medicine (Baltimore). 2014 Oct;93(17):236-254
pubmed: 25398060
Sci Immunol. 2018 Dec 21;3(30):
pubmed: 30578352
Clin Infect Dis. 1992 Mar;14(3):662-5
pubmed: 1562657
Clin Infect Dis. 2000 Feb;30(2):356-62
pubmed: 10671341
Case Rep Med. 2014;2014:362845
pubmed: 25024707
J Clin Immunol. 2020 Jan;40(1):66-81
pubmed: 32048120
Lancet Infect Dis. 2010 Dec;10(12):875-85
pubmed: 21109174
BMJ Case Rep. 2016 May 11;2016:
pubmed: 27170615
Clin Infect Dis. 2005 Dec 15;41(12):1772-82
pubmed: 16288403
J Infect Dis. 2003 Nov 1;188(9):1332-5
pubmed: 14593590
Clin Infect Dis. 2017 Oct 1;65(7):1136-1143
pubmed: 28575173
J Community Hosp Intern Med Perspect. 2020 May 21;10(2):168-170
pubmed: 32850058
J Allergy Clin Immunol. 2008 Dec;122(6):1043-51; quiz 1052-3
pubmed: 19084105
J Clin Immunol. 2019 Jul;39(5):512-518
pubmed: 31177358
Semin Immunol. 2014 Dec;26(6):454-70
pubmed: 25453225
Case Rep Urol. 2013;2013:821526
pubmed: 23844314
Med Mal Infect. 2019 Aug;49(5):350-355
pubmed: 30583869
N Engl J Med. 2007 Feb 8;356(6):567-79
pubmed: 17287477
J Clin Invest. 2005 Sep;115(9):2480-8
pubmed: 16127458
J Allergy Clin Immunol Pract. 2020 Apr;8(4):1371-1386
pubmed: 32006723