Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
12 Aug 2021
12 Aug 2021
Historique:
received:
12
05
2021
accepted:
08
07
2021
entrez:
20
8
2021
pubmed:
21
8
2021
medline:
21
8
2021
Statut:
epublish
Résumé
Soluble adenylyl cyclase (sAC) has gained attention as a potential therapeutic target given the role of this enzyme in intracellular signaling. We describe successful efforts to design improved sAC inhibitors amenable for
Identifiants
pubmed: 34413957
doi: 10.1021/acsmedchemlett.1c00273
pmc: PMC8366019
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1283-1287Subventions
Organisme : NIA NIH HHS
ID : F31 AG069501
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD088571
Pays : United States
Organisme : NICHD NIH HHS
ID : F31 HD105363
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD100549
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061290
Pays : United States
Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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