Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
12 Aug 2021
12 Aug 2021
Historique:
received:
09
06
2021
accepted:
21
07
2021
entrez:
20
8
2021
pubmed:
21
8
2021
medline:
21
8
2021
Statut:
epublish
Résumé
In the context of drug repositioning and expanding the existing structure-activity relationship around astemizole (AST), a new series of analogues were designed, synthesized, and evaluated for their antiplasmodium activity. Among 46 analogues tested, compounds
Identifiants
pubmed: 34413963
doi: 10.1021/acsmedchemlett.1c00328
pmc: PMC8366009
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1333-1341Informations de copyright
© 2021 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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