Identification of effective natural PIK3CA H1047R inhibitors by computational study.
Binding Sites
Class I Phosphatidylinositol 3-Kinases
/ antagonists & inhibitors
Computational Biology
Drug Screening Assays, Antitumor
Enzyme Inhibitors
/ chemistry
Female
Humans
Ligands
Models, Molecular
Mutation, Missense
Phenylurea Compounds
/ chemistry
Pyrimidines
/ chemistry
Signal Transduction
Triple Negative Breast Neoplasms
/ enzymology
Wortmannin
/ chemistry
PIK3CA H1047R
TNBC
drug development
targeted therapy
virtual screening
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
20 08 2021
20 08 2021
Historique:
received:
20
05
2021
accepted:
03
08
2021
pubmed:
21
8
2021
medline:
20
1
2022
entrez:
20
8
2021
Statut:
ppublish
Résumé
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with a poor prognosis and a high recurrence rate.
Identifiants
pubmed: 34415239
pii: 203409
doi: 10.18632/aging.203409
pmc: PMC8436935
doi:
Substances chimiques
Enzyme Inhibitors
0
Ligands
0
PKI 402
0
Phenylurea Compounds
0
Pyrimidines
0
Class I Phosphatidylinositol 3-Kinases
EC 2.7.1.137
PIK3CA protein, human
EC 2.7.1.137
Wortmannin
XVA4O219QW
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20246-20257Références
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